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Solid-phase synthesis of ?-lactams, ?-lactones and cyclobutane derivatives from common resin-bound intermediates

Solid-phase synthesis of ?-lactams, ?-lactones and cyclobutane derivatives from common resin-bound intermediates
Solid-phase synthesis of ?-lactams, ?-lactones and cyclobutane derivatives from common resin-bound intermediates
Resin-bound cyclobutanone iminium salts, prepared on the solid-phase using the [2+2]-keteneiminium olefin cycloaddition reaction, have been transformed into a number of distinct structural classes including ?-lactams, ?-lactones, cyclobutylamines and cyclobutanols.
solid-phase synthesis, [2+2] cycloaddition, gamma-lactams, gamma-lactones, cyclobutylamines, cyclobutanols, cyclobutanonesstrategy, inhibition, analogs
0040-4039
3247-3251
Brown, R. C. D.
fd92f80c-255a-4e51-861a-5ee85835bfcf
Keily, J.
e14223c1-be1e-4f3a-bf82-08a1abe01b52
Karim, R.
154944a0-d0ee-4323-a244-5b8622f2ef78
Brown, R. C. D.
fd92f80c-255a-4e51-861a-5ee85835bfcf
Keily, J.
e14223c1-be1e-4f3a-bf82-08a1abe01b52
Karim, R.
154944a0-d0ee-4323-a244-5b8622f2ef78

Brown, R. C. D., Keily, J. and Karim, R. (2000) Solid-phase synthesis of ?-lactams, ?-lactones and cyclobutane derivatives from common resin-bound intermediates. Tetrahedron Letters, 41 (17), 3247-3251. (doi:10.1016/S0040-4039(00)00359-2).

Record type: Article

Abstract

Resin-bound cyclobutanone iminium salts, prepared on the solid-phase using the [2+2]-keteneiminium olefin cycloaddition reaction, have been transformed into a number of distinct structural classes including ?-lactams, ?-lactones, cyclobutylamines and cyclobutanols.

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More information

Published date: 22 April 2000
Keywords: solid-phase synthesis, [2+2] cycloaddition, gamma-lactams, gamma-lactones, cyclobutylamines, cyclobutanols, cyclobutanonesstrategy, inhibition, analogs
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Identifiers

Local EPrints ID: 18908
URI: http://eprints.soton.ac.uk/id/eprint/18908
DOI: doi:10.1016/S0040-4039(00)00359-2
ISSN: 0040-4039
PURE UUID: 1fdb7115-949b-4132-9ff6-9dfa0b039c3e

Catalogue record

Date deposited: 15 Dec 2005
Last modified: 15 Mar 2024 06:09

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Contributors

Author: R. C. D. Brown
Author: J. Keily
Author: R. Karim

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