Solid-phase synthesis of cyclic sulfonamides employing a ring-closing metathesis-cleavage strategy

Brown, R. C. D., Castro, J. L. and Moriggi, J. D. (2000) Solid-phase synthesis of cyclic sulfonamides employing a ring-closing metathesis-cleavage strategy. Tetrahedron Letters, 41 (19), 3681-3685. (doi:10.1016/S0040-4039(00)00442-1).

Abstract

Ring-closing olefin metathesis using the Grubbs catalyst was applied to the cyclisative release of resin-bound sulfonamides. Flexible linkers apparently facilitated the cyclisation-leavage, allowing a number of novel cyclic sulfonamides to be prepared in good yields using catalytic amounts of the Grubbs catalyst.

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