Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads


Basso, A., Pegg, N., Evans, B. and Bradley, M. (2000) Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads European Journal of Organic Chemistry, (23), pp. 3887-3891. (doi:10.1002/1099-0690(200012)2000:23<3887::AID-EJOC3887>3.0.CO;2-T).

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Description/Abstract

Many amidine-based molecules are known to be antagonists of the fibrinogen-GP IIb-IIIa interaction, therefore useful in the treatment of thrombotic deseases. Here we report the solid-phase synthesis of a small library of amidines, starting from high-loading dendrimerised TentaGel beads, using resin-bound 4-amidinobenzoic acid as a template. These compounds mimic the structure of known active compounds like Lamifiban (Ro44-9883) and TAK-029; the first solid-phase synthesis of which is also reported in this paper.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/1099-0690(200012)2000:23<3887::AID-EJOC3887>3.0.CO;2-T
ISSNs: 1434-193X (print)
Related URLs:
Keywords: solid-phase organic synthesis, dendrimers, amidines, ro44-9883 fibrinogen receptor antagonists, peptide-synthesis, inhibitors, derivatives, reagent, design
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ePrint ID: 18911
Date :
Date Event
1 December 2000Published
Date Deposited: 17 Jan 2006
Last Modified: 16 Apr 2017 23:08
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/18911

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