A selenide linker for "traceless" solid-phase organic synthesis
A selenide linker for "traceless" solid-phase organic synthesis
4-Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase resins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides.
solid-phase synthesis, traceless linkers, selenides
strategies, cleavage
104-106
Li, Z. G.
166e9d42-b238-4112-8145-8172a3d024ea
Kulkarni, B. A.
780354e8-3ad9-49fa-96a5-8f5890179306
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
2000
Li, Z. G.
166e9d42-b238-4112-8145-8172a3d024ea
Kulkarni, B. A.
780354e8-3ad9-49fa-96a5-8f5890179306
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Abstract
4-Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase resins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides.
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Published date: 2000
Keywords:
solid-phase synthesis, traceless linkers, selenides
strategies, cleavage
Identifiers
Local EPrints ID: 18917
URI: http://eprints.soton.ac.uk/id/eprint/18917
ISSN: 0006-3592
PURE UUID: e68a84dc-2ab0-412f-913c-e251f6546c4a
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Date deposited: 18 Jan 2006
Last modified: 15 Mar 2024 06:09
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Contributors
Author:
Z. G. Li
Author:
B. A. Kulkarni
Author:
A. Ganesan
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