Li, Z. G., Kulkarni, B. A. and Ganesan, A.
A selenide linker for "traceless" solid-phase organic synthesis
Biotechnology and Bioengineering, 71, (2), . (doi:10.1002/1097-0290(2000)71:2<104::AID-BIT1000>3.0.CO;2-7).
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4-Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase resins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides.
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