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A safety-catch linker for amine release under biologically compatible conditions

Orain, D. and Bradley, M. (2000) A safety-catch linker for amine release under biologically compatible conditions Molecular Diversity, 5, (1), pp. 25-34. (doi:10.1023/A:1011355300910).

Record type: Article


A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.

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Published date: 2000
Keywords: amines, diketopiperazine, solid phase organic synthesis (spos) solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage


Local EPrints ID: 18919
PURE UUID: 26eecfd0-3acd-4065-9022-c516aabdfe77

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Date deposited: 19 Jan 2006
Last modified: 17 Jul 2017 16:34

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Author: D. Orain
Author: M. Bradley

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