The University of Southampton
University of Southampton Institutional Repository

A safety-catch linker for amine release under biologically compatible conditions

Record type: Article

A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.

Full text not available from this repository.

Citation

Orain, D. and Bradley, M. (2000) A safety-catch linker for amine release under biologically compatible conditions Molecular Diversity, 5, (1), pp. 25-34. (doi:10.1023/A:1011355300910).

More information

Published date: 2000
Keywords: amines, diketopiperazine, solid phase organic synthesis (spos) solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage

Identifiers

Local EPrints ID: 18919
URI: http://eprints.soton.ac.uk/id/eprint/18919
PURE UUID: 26eecfd0-3acd-4065-9022-c516aabdfe77

Catalogue record

Date deposited: 19 Jan 2006
Last modified: 17 Jul 2017 16:34

Export record

Altmetrics

Contributors

Author: D. Orain
Author: M. Bradley

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×