A safety-catch linker for amine release under biologically compatible conditions


Orain, D. and Bradley, M. (2000) A safety-catch linker for amine release under biologically compatible conditions Molecular Diversity, 5, (1), pp. 25-34. (doi:10.1023/A:1011355300910).

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Description/Abstract

A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1023/A:1011355300910
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Keywords: amines, diketopiperazine, solid phase organic synthesis (spos) solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage
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ePrint ID: 18919
Date :
Date Event
2000Published
Date Deposited: 19 Jan 2006
Last Modified: 16 Apr 2017 23:08
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/18919

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