Tissue engineered models: a valuable tool in pressure
ulcer research
Tissue engineered models: a valuable tool in pressure
ulcer research
Until the last two decades, research on the aetiology of pressure ulcers was primarily based on animal models, using rabbits, pigs, rats and dogs. Although these studies have been very valuable, there are ethical as well as conceptual reasons to look for alternative models. Sophisticated non-invasive techniques like Magnetic Resonance Imaging (MRI) and Ultrasound as well as advanced theoretical modelling have offered opportunities for studies with human volunteers. This chapter describes the activities in the laboratories of the authors in the last 15 years which have focused on the aetiology of pressure ulcers. This includes in vitro studies on single cells and on artificial skeletal muscle tissues. These investigations have provided considerable insight into aspects of deformation damage and the role of ischemia in pressure ulcer development. The results appeared consistent with animal studies and human studies
978-3-642-00533-6
249-262
Oomens, Cees
b443883d-b615-4e45-86c4-dcc9c3c74431
Bader, Dan
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
2009
Oomens, Cees
b443883d-b615-4e45-86c4-dcc9c3c74431
Bader, Dan
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Oomens, Cees and Bader, Dan
(2009)
Tissue engineered models: a valuable tool in pressure
ulcer research.
In,
Gefen, Amit
(ed.)
Bioengineering Research of Chronic Wounds.
(Studies in Mechanobiology, Tissue Engineering and Biomaterials, 1)
Heidelberg, DE.
Springer, .
(doi:10.1007/978-3-642-00534-3_11).
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Abstract
Until the last two decades, research on the aetiology of pressure ulcers was primarily based on animal models, using rabbits, pigs, rats and dogs. Although these studies have been very valuable, there are ethical as well as conceptual reasons to look for alternative models. Sophisticated non-invasive techniques like Magnetic Resonance Imaging (MRI) and Ultrasound as well as advanced theoretical modelling have offered opportunities for studies with human volunteers. This chapter describes the activities in the laboratories of the authors in the last 15 years which have focused on the aetiology of pressure ulcers. This includes in vitro studies on single cells and on artificial skeletal muscle tissues. These investigations have provided considerable insight into aspects of deformation damage and the role of ischemia in pressure ulcer development. The results appeared consistent with animal studies and human studies
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Published date: 2009
Identifiers
Local EPrints ID: 189297
URI: http://eprints.soton.ac.uk/id/eprint/189297
ISBN: 978-3-642-00533-6
PURE UUID: 68aa12f9-b777-4d48-9bf7-168972b815cf
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Date deposited: 02 Jun 2011 10:42
Last modified: 14 Mar 2024 03:35
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Author:
Cees Oomens
Editor:
Amit Gefen
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