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Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue

Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue
Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue
Mechanical loading of soft tissues covering bony prominences can cause skeletal muscle damage, ultimately resulting in a severe pressure ulcer termed deep tissue injury. Recently, by means of an experimental-numerical approach, it was shown that local tissue deformations cause tissue damage once a deformation threshold is exceeded. In the present study, the effects of load exposure time and intermittent load relief on the development of deformation-induced muscle damage were investigated. The data showed that a 2 h loading period caused more damage than 10 min loading. Intermittent load reliefs of 2 min during a 2 h loading period had minimal effect on the evolution of skeletal muscle damage. In addition, a local deformation threshold for damage was found, which was similar for each of the loading regimes applied in this study. For short loading periods, these results imply that local tissue deformations determine whether muscle damage will develop and the exposure time influences the amount of tissue damage. Temporary load reliefs were inefficient in reducing deformation-induced damage, but may still influence the development of ischemia-induced damage during longer loading periods
pressure ulcers, deep tissue injury, magnetic resonance imaging, finite element modeling, damage threshold
0090-6964
2577-2587
Loerakker, S.
129b8e14-e50a-4858-ae3d-5b2eeac4448f
Stekelenburg, A.
81bba22a-0eb4-48fa-9504-2faa5c174366
Strijkers, G.j.
59801515-c582-4f1a-a46b-055f1bc5122b
Rijpkema, J.J.M.
8c8d3a14-8e7d-4b6b-820e-cd2d91ce8aa5
Baaijens, F.P.T.
5d9e63e2-7d7b-4f64-b942-29121121dce0
Bader, D.L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Nicolay, K.
c55ab2c0-0ba1-49ef-a554-ff3e42e891dc
Oomens, C.W.J.
a8310c52-8ab4-4652-b2d6-82269a3c7438
Loerakker, S.
129b8e14-e50a-4858-ae3d-5b2eeac4448f
Stekelenburg, A.
81bba22a-0eb4-48fa-9504-2faa5c174366
Strijkers, G.j.
59801515-c582-4f1a-a46b-055f1bc5122b
Rijpkema, J.J.M.
8c8d3a14-8e7d-4b6b-820e-cd2d91ce8aa5
Baaijens, F.P.T.
5d9e63e2-7d7b-4f64-b942-29121121dce0
Bader, D.L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Nicolay, K.
c55ab2c0-0ba1-49ef-a554-ff3e42e891dc
Oomens, C.W.J.
a8310c52-8ab4-4652-b2d6-82269a3c7438

Loerakker, S., Stekelenburg, A., Strijkers, G.j., Rijpkema, J.J.M., Baaijens, F.P.T., Bader, D.L., Nicolay, K. and Oomens, C.W.J. (2010) Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue. Annals of Biomedical Engineering, 38 (8), 2577-2587. (doi:10.1007/s10439-010-0002-x). (PMID:20232152)

Record type: Article

Abstract

Mechanical loading of soft tissues covering bony prominences can cause skeletal muscle damage, ultimately resulting in a severe pressure ulcer termed deep tissue injury. Recently, by means of an experimental-numerical approach, it was shown that local tissue deformations cause tissue damage once a deformation threshold is exceeded. In the present study, the effects of load exposure time and intermittent load relief on the development of deformation-induced muscle damage were investigated. The data showed that a 2 h loading period caused more damage than 10 min loading. Intermittent load reliefs of 2 min during a 2 h loading period had minimal effect on the evolution of skeletal muscle damage. In addition, a local deformation threshold for damage was found, which was similar for each of the loading regimes applied in this study. For short loading periods, these results imply that local tissue deformations determine whether muscle damage will develop and the exposure time influences the amount of tissue damage. Temporary load reliefs were inefficient in reducing deformation-induced damage, but may still influence the development of ischemia-induced damage during longer loading periods

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Published date: August 2010
Keywords: pressure ulcers, deep tissue injury, magnetic resonance imaging, finite element modeling, damage threshold

Identifiers

Local EPrints ID: 189381
URI: http://eprints.soton.ac.uk/id/eprint/189381
ISSN: 0090-6964
PURE UUID: e516eaea-b8cc-40e1-bd3b-59caca620306
ORCID for D.L. Bader: ORCID iD orcid.org/0000-0002-1208-3507

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Date deposited: 03 Jun 2011 08:38
Last modified: 14 Mar 2024 03:35

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Contributors

Author: S. Loerakker
Author: A. Stekelenburg
Author: G.j. Strijkers
Author: J.J.M. Rijpkema
Author: F.P.T. Baaijens
Author: D.L. Bader ORCID iD
Author: K. Nicolay
Author: C.W.J. Oomens

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