A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis


May, P. J., Bradley, M., Harrowven, D. C. and Pallin, D. (2000) A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis Tetrahedron Letters, 41, (10), pp. 1627-1630. (doi:10.1016/S0040-4039(99)02345-X).

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Description/Abstract

Resin bound thioesters can be prepared by heating thioamides in aqueous DMF with Merrifield resin in the presence of sodium iodide. These thioamides can be cleaved to give alcohols, ketones and lactones by a variety of methods.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0040-4039(99)02345-X
ISSNs: 0040-4039 (print)
Keywords: combinatorial chemistry, lactones, solid phase synthesis, thioamide, thioestersilyl enol ethers, organic-synthesis, esters
Subjects:
ePrint ID: 18951
Date :
Date Event
4 March 2000Published
Date Deposited: 15 Dec 2005
Last Modified: 16 Apr 2017 23:08
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/18951

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