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Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound

Roth, Simon, Baudin, Jenny, Stewart, Ann L., Neville, Brian G. R. and Wyatt, John S. (2003) Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound Pediatrics, 112, (5), pp. 1108-1114. (doi:10.1542/peds.112.5.1108). (PMID:14595054).

Record type: Article


Objectives. To investigate the effect of gestational age at birth on the frequency of ultrasound-detected brain lesions in infants born at <33 weeks of gestation and to investigate whether the relationship between neonatal cranial ultrasound diagnosis and neurodevelopmental outcome at 8 years of age was independent of gestational age.

Methods. Eight hundred forty-seven infants born at <33 weeks of gestation, admitted to a single tertiary referral center between 1983 and 1988, underwent serial neonatal cranial ultrasound. At 8 years of age neurodevelopmental outcome was assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for Children), tests of visuomotor integration (Beery) and motor impairment (Henderson-Stott). Infants were subdivided into a group born at <28 weeks and a group born at between 28 and 32 weeks. Neurodevelopmental outcome was analyzed for each ultrasound diagnosis.

Results. Hemorrhagic lesions such as germinal matrix/intraventricular hemorrhage and hemorrhagic parenchymal infarction were more frequent in infants born at <28 weeks. There was no difference in the frequency of cystic periventricular leucomalacia between the 2 groups. When neurodevelopmental outcome for each ultrasound diagnosis was compared, no significant difference was found between the 2 gestational age groups.

Conclusion. In the gestational age range studied, adverse neurodevelopmental outcome depends primarily on the type of the intracranial lesion rather than on gestational age.

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Published date: 1 November 2003


Local EPrints ID: 189523
ISSN: 0031-4005
PURE UUID: 319c21a1-28b1-4e6d-8fc2-559dc7de42f9

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Date deposited: 02 Jun 2011 14:38
Last modified: 21 Aug 2017 16:32

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Author: Simon Roth
Author: Jenny Baudin
Author: Ann L. Stewart
Author: Brian G. R. Neville
Author: John S. Wyatt

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