MRI of the brain was performed on 56 children with bilateral spastic cerebral palsy (CP) at a mean age of 10.7 years. Specific pathology was found in 91 per cent; periventricular leukomalacia was present in 42 per cent of term- and 87 per cent of preterm-born children. Parasagittal subcorticocortical injury, multicystic encephalomalacia and basal ganglia lesions were identified in 16 per cent, in all but one associated with severe peri-/neonatal events at term or near term. Maldevelopment comprised 9 per cent, all but one found in term-born children. MRI morphology correlated strikingly with outcome. Periventricular leukomalacia was associated with more severe disability in term- than preterm-born children.
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Krägeloh-Mann, Ingeborg, Petersen, Dirk, Hagberg, Gudrun, Hagberg, Bengt and Michaelis, Richard (1995) Bilateral spastic cerebral palsy--MRI pathology and origin. Analysis from a representative series of 56 cases. Developmental Medicine and Child Neurology, 37, (5), pp. 379-397. (doi:10.1111/j.1469-8749.1995.tb12022.x). (PMID:8566452).
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