Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress
Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress
The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.
bilayer-forming lipids, phosphatidylcholine biosynthesis, acholeplasma-laidlawii, binding domain, phase-behavior, 1-o-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine, lysophosphatidylcholine, cells, phospholipids, cholesterol
9032-9036
Attard, G. S.
15b1b53e-25e4-4c5b-bc58-3601527f90d9
Templer, R. H.
9bd38d7a-18b6-4af4-b683-846c035bb4b9
Smith, W. S.
0722bfa1-73fa-4396-961b-dba3143fb915
Hunt, Alan
95a3e223-da96-40e7-b47d-27dce014e305
Jackowski, S.
7338eae6-4c3a-4a75-abe0-aa2abbf70560
1 August 2000
Attard, G. S.
15b1b53e-25e4-4c5b-bc58-3601527f90d9
Templer, R. H.
9bd38d7a-18b6-4af4-b683-846c035bb4b9
Smith, W. S.
0722bfa1-73fa-4396-961b-dba3143fb915
Hunt, Alan
95a3e223-da96-40e7-b47d-27dce014e305
Jackowski, S.
7338eae6-4c3a-4a75-abe0-aa2abbf70560
Attard, G. S., Templer, R. H., Smith, W. S., Hunt, Alan and Jackowski, S.
(2000)
Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress.
Proceedings of the National Academy of Sciences of the United States of America, 97 (16), .
(doi:10.1073/pnas.160260697).
Abstract
The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.
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Published date: 1 August 2000
Keywords:
bilayer-forming lipids, phosphatidylcholine biosynthesis, acholeplasma-laidlawii, binding domain, phase-behavior, 1-o-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine, lysophosphatidylcholine, cells, phospholipids, cholesterol
Organisations:
Chemistry
Identifiers
Local EPrints ID: 18967
URI: http://eprints.soton.ac.uk/id/eprint/18967
ISSN: 0027-8424
PURE UUID: b1afa14b-5f8c-448c-9572-344db31162e6
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Date deposited: 19 Jan 2006
Last modified: 16 Mar 2024 02:48
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Author:
G. S. Attard
Author:
R. H. Templer
Author:
W. S. Smith
Author:
Alan Hunt
Author:
S. Jackowski
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