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Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress

Attard, G. S., Templer, R. H., Smith, W. S., Hunt, A. N. and Jackowski, S. (2000) Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress Proceedings of the National Academy of Sciences, 97, (16), pp. 9032-9036. (doi:10.1073/pnas.160260697).

Record type: Article


The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.

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Published date: 1 August 2000
Keywords: bilayer-forming lipids, phosphatidylcholine biosynthesis, acholeplasma-laidlawii, binding domain, phase-behavior, 1-o-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine, lysophosphatidylcholine, cells, phospholipids, cholesterol
Organisations: Chemistry


Local EPrints ID: 18967
ISSN: 0027-8424
PURE UUID: b1afa14b-5f8c-448c-9572-344db31162e6

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Date deposited: 19 Jan 2006
Last modified: 17 Jul 2017 16:34

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Author: G. S. Attard
Author: R. H. Templer
Author: W. S. Smith
Author: A. N. Hunt
Author: S. Jackowski

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