Sex difference in composition of plaques of patients undergoing carotid endarterectomy
Sex difference in composition of plaques of patients undergoing carotid endarterectomy
Our study aimed to examine the hypothesis that women have more stable plaques (a lower proportion of lipid component and a higher proportion of fibrous tissue) compared to men. Plaque specimens of 141 consecutive carotid endarterectomy patients (60 females and 81 males) were studied. Medical histories were recorded and the plasma concentrations of cholesterol and inflammatory markers were measured. We found that plaques from females had significantly less lipid than those from males (p = .01): the mean percentage of plaque lipid for women and men was 47.8% and 58.2%, respectively. Plaques from females had more fibrous tissue than those from men (p = .02): the mean percentage of fibrous tissue for women and men was 38.8% and 29.8%, respectively. This study concluded that the histology of carotid artery plaques from women appears to be more stable than that of those from men.
carotid plaque, fibrous, gender, lipid, sex, unstable
77-81
Rerkasem, Kittipan
8343c03b-cdcf-4fbe-85ab-de7bf3896ca2
Gallagher, Patrick J.
14c495ef-03bd-499e-8feb-b4d8fa4508cf
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Shearman, Clifford P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
1 April 2010
Rerkasem, Kittipan
8343c03b-cdcf-4fbe-85ab-de7bf3896ca2
Gallagher, Patrick J.
14c495ef-03bd-499e-8feb-b4d8fa4508cf
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Shearman, Clifford P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
Rerkasem, Kittipan, Gallagher, Patrick J., Grimble, Robert F., Calder, Philip C. and Shearman, Clifford P.
(2010)
Sex difference in composition of plaques of patients undergoing carotid endarterectomy.
Vascular, 18 (2), .
(doi:10.2310/6670.2010.00008).
(PMID:20338131)
Abstract
Our study aimed to examine the hypothesis that women have more stable plaques (a lower proportion of lipid component and a higher proportion of fibrous tissue) compared to men. Plaque specimens of 141 consecutive carotid endarterectomy patients (60 females and 81 males) were studied. Medical histories were recorded and the plasma concentrations of cholesterol and inflammatory markers were measured. We found that plaques from females had significantly less lipid than those from males (p = .01): the mean percentage of plaque lipid for women and men was 47.8% and 58.2%, respectively. Plaques from females had more fibrous tissue than those from men (p = .02): the mean percentage of fibrous tissue for women and men was 38.8% and 29.8%, respectively. This study concluded that the histology of carotid artery plaques from women appears to be more stable than that of those from men.
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Published date: 1 April 2010
Keywords:
carotid plaque, fibrous, gender, lipid, sex, unstable
Organisations:
Dev Origins of Health & Disease
Identifiers
Local EPrints ID: 190123
URI: http://eprints.soton.ac.uk/id/eprint/190123
ISSN: 1708-5381
PURE UUID: 1d6cd0f0-c706-4377-8ac2-5934f7b91e14
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Date deposited: 10 Jun 2011 08:32
Last modified: 15 Mar 2024 02:50
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Author:
Kittipan Rerkasem
Author:
Patrick J. Gallagher
Author:
Robert F. Grimble
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