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A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia

A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia
A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia
Respiratory muscle weakness is commonplace in critically ill patients, impairing the ability of those patients to breath, prolonging the need for ventilatory support, and increasing the likelihood of respiratory failure when that support is removed. Infections and endotoxemia reduce respiratory muscle strength, probably acting through several mechanisms. It is reported that the omega-3 fatty acid eicosapentaenoic acid (EPA) attenuates the loss in diaphragm specific force generation (that is, diaphragm strength) induced by bacterial endotoxin treatment in rats. EPA is found in fish oils. EPA reduces calpain activation, suggesting a specific effect on this proteolytic pathway. It will be important to identify whether this effect occurs in patients receiving EPA
1364-8535
143
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Calder, Philip C. (2010) A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia. Critical Care, 14 (2), 143. (doi:10.1186/cc8951). (PMID:20429961)

Record type: Article

Abstract

Respiratory muscle weakness is commonplace in critically ill patients, impairing the ability of those patients to breath, prolonging the need for ventilatory support, and increasing the likelihood of respiratory failure when that support is removed. Infections and endotoxemia reduce respiratory muscle strength, probably acting through several mechanisms. It is reported that the omega-3 fatty acid eicosapentaenoic acid (EPA) attenuates the loss in diaphragm specific force generation (that is, diaphragm strength) induced by bacterial endotoxin treatment in rats. EPA is found in fish oils. EPA reduces calpain activation, suggesting a specific effect on this proteolytic pathway. It will be important to identify whether this effect occurs in patients receiving EPA

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Published date: April 2010

Identifiers

Local EPrints ID: 190129
URI: https://eprints.soton.ac.uk/id/eprint/190129
ISSN: 1364-8535
PURE UUID: a21d8540-e450-4335-9ed7-02ab8dcf3c67

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Date deposited: 10 Jun 2011 09:03
Last modified: 16 Jul 2019 23:29

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