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Cell proliferation in the repairing adult insect central nervous system: incorporation of the thymidine analogue 5-bromo-2-deoxyuridine in vivo

Cell proliferation in the repairing adult insect central nervous system: incorporation of the thymidine analogue 5-bromo-2-deoxyuridine in vivo
Cell proliferation in the repairing adult insect central nervous system: incorporation of the thymidine analogue 5-bromo-2-deoxyuridine in vivo
Uptake of the thymidine analogue 5-bromo-2-deoxyuridine into non-neuronal cells of the insect central nervous system has been examined following a controlled lesioning of the glial elements. The pattern of BUdR labelling along the penultimate abdominal connective was examined over a period of 17 days. Cell proliferation occurred in and immediately around the site of damage in both perineurial and subperineurial glial cells but at different times post-lesion for the two regions. Proliferation in the perineurial zone was maximal at 6-8 days post-lesion but continued for at least 17 days. Subperineurial proliferation was less dramatic and peaked between days 8-11 post-lesion. In both areas division appears to be confined to the reactive glial cells. These results are discussed in the context of past research on this system, particularly with regard to the restoration of the blood-brain barrier.
0021-9533
599-604
Smith, P.J.
003de469-9420-4f12-8f0e-8e8d76d28d6c
Howes, E.A.
373174b7-4c56-4feb-84da-6b2779ab5fbe
Treherne, J.E.
585f48d3-4b89-4132-81ce-08f2b1770238
Smith, P.J.
003de469-9420-4f12-8f0e-8e8d76d28d6c
Howes, E.A.
373174b7-4c56-4feb-84da-6b2779ab5fbe
Treherne, J.E.
585f48d3-4b89-4132-81ce-08f2b1770238

Smith, P.J., Howes, E.A. and Treherne, J.E. (1990) Cell proliferation in the repairing adult insect central nervous system: incorporation of the thymidine analogue 5-bromo-2-deoxyuridine in vivo. Journal of Cell Science, 95 (4), 599-604. (PMID:2384529)

Record type: Article

Abstract

Uptake of the thymidine analogue 5-bromo-2-deoxyuridine into non-neuronal cells of the insect central nervous system has been examined following a controlled lesioning of the glial elements. The pattern of BUdR labelling along the penultimate abdominal connective was examined over a period of 17 days. Cell proliferation occurred in and immediately around the site of damage in both perineurial and subperineurial glial cells but at different times post-lesion for the two regions. Proliferation in the perineurial zone was maximal at 6-8 days post-lesion but continued for at least 17 days. Subperineurial proliferation was less dramatic and peaked between days 8-11 post-lesion. In both areas division appears to be confined to the reactive glial cells. These results are discussed in the context of past research on this system, particularly with regard to the restoration of the blood-brain barrier.

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Published date: April 1990

Identifiers

Local EPrints ID: 190289
URI: https://eprints.soton.ac.uk/id/eprint/190289
ISSN: 0021-9533
PURE UUID: 8a561bdf-b946-4bc6-85c3-5bcbe77f26d9
ORCID for P.J. Smith: ORCID iD orcid.org/0000-0003-4400-6853

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Date deposited: 17 Jun 2011 10:26
Last modified: 06 Jun 2018 12:31

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Contributors

Author: P.J. Smith ORCID iD
Author: E.A. Howes
Author: J.E. Treherne

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