Mechanisms of glial regeneration in an insect central nervous system
Mechanisms of glial regeneration in an insect central nervous system
As in other repairing systems, glial regeneration in insect central nervous connectives, following selective chemical lesioning, involves both exogenous and endogenous elements. Our current evidence, including that obtained with monoclonal antibodies, indicates that the reactive, granule-containing cells are derived from a sub-population of circulating haemocytes which, within 24 h, invade, and are restricted to, the lesion zone. The granule-containing cells are involved in the initial repair of the perineurial region. They also contribute to the first stage in the restoration of the blood-brain barrier and are responsible for recruiting reactive endogenous glia, apparently from the vicinity of the anterior abdominal ganglion. The granule-containing cells transform into or are replaced by functional glia between 3 and 5 days after selective glial disruption, coincident with the appearance in the lesion zone of dividing reactive cells.
59-78
Smith, P.J.
003de469-9420-4f12-8f0e-8e8d76d28d6c
Howes, E.A.
373174b7-4c56-4feb-84da-6b2779ab5fbe
Treherne, J.E.
585f48d3-4b89-4132-81ce-08f2b1770238
September 1987
Smith, P.J.
003de469-9420-4f12-8f0e-8e8d76d28d6c
Howes, E.A.
373174b7-4c56-4feb-84da-6b2779ab5fbe
Treherne, J.E.
585f48d3-4b89-4132-81ce-08f2b1770238
Smith, P.J., Howes, E.A. and Treherne, J.E.
(1987)
Mechanisms of glial regeneration in an insect central nervous system.
Journal of Experimental Biology, 132, .
(PMID:3323407)
Abstract
As in other repairing systems, glial regeneration in insect central nervous connectives, following selective chemical lesioning, involves both exogenous and endogenous elements. Our current evidence, including that obtained with monoclonal antibodies, indicates that the reactive, granule-containing cells are derived from a sub-population of circulating haemocytes which, within 24 h, invade, and are restricted to, the lesion zone. The granule-containing cells are involved in the initial repair of the perineurial region. They also contribute to the first stage in the restoration of the blood-brain barrier and are responsible for recruiting reactive endogenous glia, apparently from the vicinity of the anterior abdominal ganglion. The granule-containing cells transform into or are replaced by functional glia between 3 and 5 days after selective glial disruption, coincident with the appearance in the lesion zone of dividing reactive cells.
Text
59.full.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: September 1987
Identifiers
Local EPrints ID: 190299
URI: http://eprints.soton.ac.uk/id/eprint/190299
ISSN: 0022-0949
PURE UUID: 71039371-bca2-43de-b183-aa4a7082e8f0
Catalogue record
Date deposited: 16 Jun 2011 15:19
Last modified: 15 Mar 2024 03:38
Export record
Contributors
Author:
E.A. Howes
Author:
J.E. Treherne
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
