The University of Southampton
University of Southampton Institutional Repository

Regenerating adult cockroach dorsal unpaired median neurones in vitro retain their in vivo membrane characteristics

Record type: Article

The ability of differentiated neurones to recover from disease or injury depends upon both intrinsic and extrinsic factors. Whereas most mammalian neurones have a limited capacity for regeneration, regulated, in part, by physical and chemical cues in the brain microenvironment (Bray et al. 1987; Caroni and Schwab, 1988, 1989), invertebrates, and in particular insects, exhibit a far greater capacity for repair of central neurones and circuits (Treherne et al. 1988). Studies of the cues that regulate the regenerative process are made easier by the use of individual, identified neurones, cultured under controlled conditions. Invertebrates are particularly useful in this regard; neurones from mature nervous systems of both annelids and molluscs have been grown successfully in culture and their growth can be influenced by changes in the culture conditions (Acklin and Nicholls, 1990; Dagan and Levitan, 1981; Ready and Nicholls, 1979; Syed et al. 1990). Routine and long-term culture of identified neurones from the insect central nervous system (CNS) has proved more elusive, preventing the use of neurones from these well-studied systems. Recently, however, cultures of cockroach (Howes et al. 1991), locust (Kirchoff and Bicker, 1992) and moth (Hayashi and Levine, 1992) adult neurones have been described.

PDF 323.full.pdf - Version of Record
Restricted to Repository staff only
Download (121kB)

Citation

Newland, N.L., Smith, P.J.S. and Howes, E.A. (1993) Regenerating adult cockroach dorsal unpaired median neurones in vitro retain their in vivo membrane characteristics Journal of Experimental Biology, 179, (1), pp. 323-329.

More information

Published date: 1 June 1993

Identifiers

Local EPrints ID: 190569
URI: http://eprints.soton.ac.uk/id/eprint/190569
ISSN: 0022-0949
PURE UUID: b196cc3a-44f7-4c44-84ed-20bb54959bc0
ORCID for P.J.S. Smith: ORCID iD orcid.org/0000-0003-4400-6853

Catalogue record

Date deposited: 16 Jun 2011 12:50
Last modified: 18 Jul 2017 11:37

Export record

Contributors

Author: N.L. Newland
Author: P.J.S. Smith ORCID iD
Author: E.A. Howes

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×