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Interactions of dietary whole-grain intake with fasting glucose-and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies

Interactions of dietary whole-grain intake with fasting glucose-and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
Interactions of dietary whole-grain intake with fasting glucose-and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
Objective: Whole grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.

Research Design & Methods: Via meta-analysis of data from 14 cohorts comprising approximately 48,000 participants of European descent, we studied interactions of whole grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a p-value <0.0028 (0.05/18 tests) as statistically significant.

Results: Greater whole grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (? [95% CI] per 1-serving greater whole grain intake: ?0.009 mmol/L glucose [?0.013, ?0.005], p <0.0001 and ?0.011 pmol/L (ln) insulin [?0.015, ?0.007], p =0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole grain intake was rs780094 (GCKR) for fasting insulin (p = 0.006), where greater whole grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.

Conclusions: Our results support the favorable association of whole grain intake with fasting glucose and insulin and suggest potential interaction between variation in GCKR and whole grain intake in influencing fasting insulin concentrations.
1935-5548
2684-2691
Nettleton, Jennifer A.
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McKeown, Nicola M.
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Kanoni, Stavroula
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Lemaitre, Rozenn N.
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Hivert, Marie-France
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Ngwa, Julius
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van Rooij, Frank J.A.
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Sonestedt, Emily
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Wojczynski, Mary K
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Ye, Zheng
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Tanaka, Tosh
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Garcia, M.
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Anderson, J.S.
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Follis, J.L
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Djousse, L.
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Papoutsakis, C.
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Zillikens, M.C.
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Bandinelli, S.
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Bennett, A.J.
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Ferrucci, L.
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Forouhi, N.G.
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Groves, C.J.
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Hallmans, G.
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Harris, T.
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Hofman, A.
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Houston, D.K.
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Johansson, I.
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Kritchevsky, S.B.
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Langenberg, C.
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Launer, L.
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Liu, Y.
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Loos, R.J.
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Nalls, M.
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Orho-Melander, M.
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Renstrom, F.
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Rice, K.
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Riserus, U.
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Rolandsson, O.
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Rotter, J.I.
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Saylor, G.
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Sijbrands, E.J.
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Sjogren, P.
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Sayer, A.A.
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Syddall, H.
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Cooper, C.
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CHARGE Whole Grain Foods Study Group
Nettleton, Jennifer A.
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McKeown, Nicola M.
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Kanoni, Stavroula
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Lemaitre, Rozenn N.
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Hivert, Marie-France
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Ngwa, Julius
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van Rooij, Frank J.A.
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Sonestedt, Emily
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Wojczynski, Mary K
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Ye, Zheng
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Tanaka, Tosh
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Garcia, M.
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Anderson, J.S.
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Follis, J.L
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Djousse, L.
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Mukamal, K.
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Papoutsakis, C.
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Mozaffarian, D.
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Zillikens, M.C.
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Bandinelli, S.
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Bennett, A.J.
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Borecki, I.B.
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Feitosa, M.F.
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Ferrucci, L.
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Forouhi, N.G.
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Groves, C.J.
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Hallmans, G.
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Harris, T.
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Hofman, A.
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Houston, D.K.
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Hu, F.B.
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Johansson, I.
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Kritchevsky, S.B.
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Langenberg, C.
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Launer, L.
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Liu, Y.
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Loos, R.J.
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Nalls, M.
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Orho-Melander, M.
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Renstrom, F.
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Rice, K.
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Riserus, U.
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Rolandsson, O.
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Rotter, J.I.
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Saylor, G.
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Sijbrands, E.J.
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Sjogren, P.
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Sayer, A.A.
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Syddall, H.
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Cooper, C.
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Nettleton, Jennifer A., McKeown, Nicola M., Kanoni, Stavroula, Lemaitre, Rozenn N., Hivert, Marie-France, Ngwa, Julius, van Rooij, Frank J.A., Sonestedt, Emily, Wojczynski, Mary K, Ye, Zheng, Tanaka, Tosh, Garcia, M., Anderson, J.S., Follis, J.L, Djousse, L., Mukamal, K., Papoutsakis, C., Mozaffarian, D., Zillikens, M.C., Bandinelli, S., Bennett, A.J., Borecki, I.B., Feitosa, M.F., Ferrucci, L., Forouhi, N.G., Groves, C.J., Hallmans, G., Harris, T., Hofman, A., Houston, D.K., Hu, F.B., Johansson, I., Kritchevsky, S.B., Langenberg, C., Launer, L., Liu, Y., Loos, R.J., Nalls, M., Orho-Melander, M., Renstrom, F., Rice, K., Riserus, U., Rolandsson, O., Rotter, J.I., Saylor, G., Sijbrands, E.J., Sjogren, P., Sayer, A.A., Syddall, H. and Cooper, C. , CHARGE Whole Grain Foods Study Group (2010) Interactions of dietary whole-grain intake with fasting glucose-and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care, 33 (12), 2684-2691. (doi:10.2337/dc10-1150). (PMID:20693352)

Record type: Article

Abstract

Objective: Whole grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.

Research Design & Methods: Via meta-analysis of data from 14 cohorts comprising approximately 48,000 participants of European descent, we studied interactions of whole grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a p-value <0.0028 (0.05/18 tests) as statistically significant.

Results: Greater whole grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (? [95% CI] per 1-serving greater whole grain intake: ?0.009 mmol/L glucose [?0.013, ?0.005], p <0.0001 and ?0.011 pmol/L (ln) insulin [?0.015, ?0.007], p =0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole grain intake was rs780094 (GCKR) for fasting insulin (p = 0.006), where greater whole grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.

Conclusions: Our results support the favorable association of whole grain intake with fasting glucose and insulin and suggest potential interaction between variation in GCKR and whole grain intake in influencing fasting insulin concentrations.

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More information

Published date: December 2010

Identifiers

Local EPrints ID: 190833
URI: http://eprints.soton.ac.uk/id/eprint/190833
ISSN: 1935-5548
PURE UUID: e229239e-9a0c-4722-bbd7-923ad3b31451
ORCID for H. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 29 Jun 2011 13:59
Last modified: 18 Mar 2024 02:48

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Contributors

Author: Jennifer A. Nettleton
Author: Nicola M. McKeown
Author: Stavroula Kanoni
Author: Rozenn N. Lemaitre
Author: Marie-France Hivert
Author: Julius Ngwa
Author: Frank J.A. van Rooij
Author: Emily Sonestedt
Author: Mary K Wojczynski
Author: Zheng Ye
Author: Tosh Tanaka
Author: M. Garcia
Author: J.S. Anderson
Author: J.L Follis
Author: L. Djousse
Author: K. Mukamal
Author: C. Papoutsakis
Author: D. Mozaffarian
Author: M.C. Zillikens
Author: S. Bandinelli
Author: A.J. Bennett
Author: I.B. Borecki
Author: M.F. Feitosa
Author: L. Ferrucci
Author: N.G. Forouhi
Author: C.J. Groves
Author: G. Hallmans
Author: T. Harris
Author: A. Hofman
Author: D.K. Houston
Author: F.B. Hu
Author: I. Johansson
Author: S.B. Kritchevsky
Author: C. Langenberg
Author: L. Launer
Author: Y. Liu
Author: R.J. Loos
Author: M. Nalls
Author: M. Orho-Melander
Author: F. Renstrom
Author: K. Rice
Author: U. Riserus
Author: O. Rolandsson
Author: J.I. Rotter
Author: G. Saylor
Author: E.J. Sijbrands
Author: P. Sjogren
Author: A.A. Sayer
Author: H. Syddall ORCID iD
Author: C. Cooper ORCID iD
Corporate Author: CHARGE Whole Grain Foods Study Group

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