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Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans

Behndig, A.F., Mudway, I.S., Brown, J.L., Stenfors, N., Helleday, R., Duggan, S.T., Wilson, S.J., Boman, C., Cassee, F.R., Frew, A.J., Kelly, F.J., Sandström, T. and Blomberg, A. (2006) Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans European Respiratory Journal, 27, (2), pp. 359-365. (doi:10.1183/?09031936.06.00136904). (PMID:16452593).

Record type: Article


Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation and injury only occurring at higher concentrations. In the present study, the authors examined whether similar responses occurred in vivo, specifically whether antioxidants were upregulated following a low-dose DE challenge and investigated how these responses related to the development of airway inflammation at different levels of the respiratory tract where particle dose varies markedly. A total of 15 volunteers were exposed to DE (100 microg x m(-3) airborne particulate matter with a diameter of <10 microm for 2 h) and air in a double-blinded, randomised fashion. At 18 h post-exposure, bronchoscopy was performed with lavage and mucosal biopsies taken to assess airway redox and inflammatory status. Following DE exposure, the current authors observed an increase in bronchial mucosa neutrophil and mast cell numbers, as well as increased neutrophil numbers, interleukin-8 and myeloperoxidase concentrations in bronchial lavage. No inflammatory responses were seen in the alveolar compartment, but both reduced glutathione and urate concentrations were increased following diesel exposure. In conclusion, the lung inflammatory response to diesel exhaust is compartmentalised, related to differing antioxidant responses in the conducting airway and alveolar regions.

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Published date: February 2006
Keywords: air pollution, airway inflammation, antioxidants, diesel exhaust, glutathione, particulate matter


Local EPrints ID: 190905
ISSN: 0903-1936
PURE UUID: 4421649b-124b-4588-95b4-af76f77f271f

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Date deposited: 15 Jun 2011 14:12
Last modified: 18 Jul 2017 11:36

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Author: A.F. Behndig
Author: I.S. Mudway
Author: J.L. Brown
Author: N. Stenfors
Author: R. Helleday
Author: S.T. Duggan
Author: S.J. Wilson
Author: C. Boman
Author: F.R. Cassee
Author: A.J. Frew
Author: F.J. Kelly
Author: T. Sandström
Author: A. Blomberg

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