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Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters

Childs, Caroline E., Romijn, Tessa, Enke, Ute, Hoile, Samuel P. and Calder, Philip C. (2010) Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters Prostaglandins, Leukotrienes and Essential Fatty Acids, 83, (4), pp. 179-183. (doi:10.1016/j.plefa.2010.08.007). (PMID:20817424).

Record type: Article


Both animalandhumanstudiesdemonstratethatthedocosahexaenoicacid(DHA)contentofplasma
and/ortissuelipidsisincreasedduringpregnancy.Wehypothesisedthatincreasingthe a-linolenicacid
(ALA)orlongerchain(n-3) PUFAcontentofthematernaldietduringpregnancyinfluencesfetalfatty
acid compositionandthefetalimmunesystem.Pregnantratswerefedalow-fat(LF)soybeanoildiet,or
(n-3) richmaternaldietduringpregnancyassociatedwiththehighestexpressionofCD3(Salmon-HF)
and CD8(Linseed-HFandSalmon-HF)onfetalthymicCD3+CD8+ cells. TheLinseed-HFdietresultedin
the highestproportionofCD161+ cells withinthefetalthymus,whichcorrelatedwiththeproductionof
IL-4. ThesedataindicatethatdietaryALAsupplementationmayconfersomeofthebenefitsofLC(n-3)
PUFA duringpregnancy.Thisshouldbeexaminedinsuitablydesignedhumanstudies

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Published date: October 2010
Keywords: fetal, immune, omega-3
Organisations: Faculty of Medicine, Dev Origins of Health & Disease


Local EPrints ID: 190945
PURE UUID: 87e7c243-333d-4657-a9a4-6c7e15d4d611
ORCID for Caroline E. Childs: ORCID iD

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Date deposited: 16 Jun 2011 11:57
Last modified: 18 Jul 2017 11:36

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Author: Tessa Romijn
Author: Ute Enke
Author: Samuel P. Hoile

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