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Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters

Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters
Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters
Both animalandhumanstudiesdemonstratethatthedocosahexaenoicacid(DHA)contentofplasma
and/ortissuelipidsisincreasedduringpregnancy.Wehypothesisedthatincreasingthe a-linolenicacid
(ALA)orlongerchain(n-3) PUFAcontentofthematernaldietduringpregnancyinfluencesfetalfatty
acid compositionandthefetalimmunesystem.Pregnantratswerefedalow-fat(LF)soybeanoildiet,or
high-fat(HF)soybean,linseed,salmonorsunfloweroildietsfromconceptionto20dgestation.The
ALA-richLinseed-HFdietresultedinanequivalenteicosapentaenoicacid(EPA)statusinfetalimmune
tissuesandanequivalentDHAstatusinthefetalbraintothatachievedwiththeSalmon-HFdiet.An
(n-3) richmaternaldietduringpregnancyassociatedwiththehighestexpressionofCD3(Salmon-HF)
and CD8(Linseed-HFandSalmon-HF)onfetalthymicCD3+CD8+ cells. TheLinseed-HFdietresultedin
the highestproportionofCD161+ cells withinthefetalthymus,whichcorrelatedwiththeproductionof
IL-4. ThesedataindicatethatdietaryALAsupplementationmayconfersomeofthebenefitsofLC(n-3)
PUFA duringpregnancy.Thisshouldbeexaminedinsuitablydesignedhumanstudies
fetal, immune, omega-3
179-183
Childs, Caroline E.
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Romijn, Tessa
f3e9a868-7f08-420d-b035-724c062d69f1
Enke, Ute
6ce0db0f-82a7-42d8-a1ee-d191b6c8420c
Hoile, Samuel P.
9d7e9816-600d-45bd-ade2-dc7798bba730
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Childs, Caroline E.
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Romijn, Tessa
f3e9a868-7f08-420d-b035-724c062d69f1
Enke, Ute
6ce0db0f-82a7-42d8-a1ee-d191b6c8420c
Hoile, Samuel P.
9d7e9816-600d-45bd-ade2-dc7798bba730
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Childs, Caroline E., Romijn, Tessa, Enke, Ute, Hoile, Samuel P. and Calder, Philip C. (2010) Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. Prostaglandins, Leukotrienes and Essential Fatty Acids, 83 (4), 179-183. (doi:10.1016/j.plefa.2010.08.007). (PMID:20817424)

Record type: Article

Abstract

Both animalandhumanstudiesdemonstratethatthedocosahexaenoicacid(DHA)contentofplasma
and/ortissuelipidsisincreasedduringpregnancy.Wehypothesisedthatincreasingthe a-linolenicacid
(ALA)orlongerchain(n-3) PUFAcontentofthematernaldietduringpregnancyinfluencesfetalfatty
acid compositionandthefetalimmunesystem.Pregnantratswerefedalow-fat(LF)soybeanoildiet,or
high-fat(HF)soybean,linseed,salmonorsunfloweroildietsfromconceptionto20dgestation.The
ALA-richLinseed-HFdietresultedinanequivalenteicosapentaenoicacid(EPA)statusinfetalimmune
tissuesandanequivalentDHAstatusinthefetalbraintothatachievedwiththeSalmon-HFdiet.An
(n-3) richmaternaldietduringpregnancyassociatedwiththehighestexpressionofCD3(Salmon-HF)
and CD8(Linseed-HFandSalmon-HF)onfetalthymicCD3+CD8+ cells. TheLinseed-HFdietresultedin
the highestproportionofCD161+ cells withinthefetalthymus,whichcorrelatedwiththeproductionof
IL-4. ThesedataindicatethatdietaryALAsupplementationmayconfersomeofthebenefitsofLC(n-3)
PUFA duringpregnancy.Thisshouldbeexaminedinsuitablydesignedhumanstudies

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More information

Published date: October 2010
Keywords: fetal, immune, omega-3
Organisations: Faculty of Medicine, Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 190945
URI: http://eprints.soton.ac.uk/id/eprint/190945
PURE UUID: 87e7c243-333d-4657-a9a4-6c7e15d4d611
ORCID for Caroline E. Childs: ORCID iD orcid.org/0000-0001-6832-224X
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 16 Jun 2011 11:57
Last modified: 11 Mar 2021 02:35

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