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The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis

Montefort, S, Feather, I H, Wilson, Susan J., Haskard, D O, Lee, T H, Holgate, Stephen T. and Howarth, Peter H. (1992) The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis American Journal of Respiratory Cell and Molecular Biology, 7, (4), pp. 393-398. (PMID:1382478).

Record type: Article

Abstract

Accumulating evidence supports the importance of leukocyte-endothelial cell adhesion molecule (CAM) expression as an initiating process in tissue inflammation. To investigate the relevance of CAM expression to allergic airways inflammation, nasal biopsies from patients with perennial allergic rhinitis (n = 8) and from nonatopic healthy volunteers (n = 8) were immunostained with monoclonal antibodies directed against the CAMs, intercellular adhesion molecule-1 (ICAM-1), endothelial cell adhesion molecule-1 (ELAM-1), and vascular cell adhesion molecule-1 (VCAM-1). The endothelial staining of these CAMs was related to the number of vessels within each biopsy, delineated by a monoclonal antibody against Ulex europaeus-1 lectin bound to endothelial cells, and to the number of tissue leukocytes staining for one of the ligands of ICAM-1, the beta 2 integrin, lymphocyte function-associated antigen (LFA-1). Expression of CAMs was related to the number of infiltrating neutrophils, eosinophils, and lymphocytes identified immunohistochemically within the biopsies. ICAM-1 was the most prominent CAM present on the endothelium of the normal nasal mucosa, with less expression of ELAM-1 and only minimal or absent expression of VCAM-1. In perennial rhinitis, both ICAM-1 (P less than 0.05) and VCAM-1 (P less than 0.01) expression on endothelial cells were increased and were positively correlated in their level of expression (P less than 0.002). The number of tissue LFA-1-positive cells was significantly greater (P less than 0.05) in the biopsies from the perennial rhinitics (median, 27.3/mm2) than from the healthy controls (median, 5.3 cells/mm2). LFA-1 expression significantly correlated with the number of ICAM-1-positive vessels (P less than 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)

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More information

Published date: October 1992
Organisations: Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 190979
URI: http://eprints.soton.ac.uk/id/eprint/190979
PURE UUID: 92c846f1-09d2-43fe-88a6-0fae5363bb60

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Date deposited: 20 Jun 2011 10:11
Last modified: 18 Jul 2017 11:36

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Contributors

Author: S Montefort
Author: I H Feather
Author: Susan J. Wilson
Author: D O Haskard
Author: T H Lee

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