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Airway inflammation and atopic asthma: a comparative bronchoscopic investigation

Airway inflammation and atopic asthma: a comparative bronchoscopic investigation
Airway inflammation and atopic asthma: a comparative bronchoscopic investigation
Flexible fibre-optic bronchoscopy under local anaesthesia has been used to investigate the cellular airway events in atopic asthma. The findings have been compared to those from atopic individuals without asthma and non-atopic healthy controls, in an attempt to discern those changes relevant to clinical disease expression. Immunohistochemical and electron-microscopic analyses of airway biopsies identified that an atopic diathesis is associated with tissue eosinophil infiltration and mast cell degranulation. The eosinophilia was greatest in those atopic individuals with asthma. Flow-cytometric analysis of airway lavage revealed significantly enhanced T lymphocyte activation in clinical asthma. These findings are consistent with the hypothesis that T lymphocyte activation, through cytokine release, amplifies the tissue eosinophilia in asthma and that this combination is associated with clinical disease expression.
1018-2438
266-269
Howarth, P.H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Wilson, J.
3f1c94b6-ce87-485d-ab0d-5cde14206d72
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Wilson, S.J.
21c6875d-6870-441b-ae7a-603562a646b8
Britten, K.
f834db08-a8c2-468b-b592-33c803a7f3eb
Walls, A.F.
aaa7e455-0562-4b4c-94f5-ec29c74b1bfe
Roche, W.R.
a5135b2d-cab5-481b-887a-78611fa00bff
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Howarth, P.H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Wilson, J.
3f1c94b6-ce87-485d-ab0d-5cde14206d72
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Wilson, S.J.
21c6875d-6870-441b-ae7a-603562a646b8
Britten, K.
f834db08-a8c2-468b-b592-33c803a7f3eb
Walls, A.F.
aaa7e455-0562-4b4c-94f5-ec29c74b1bfe
Roche, W.R.
a5135b2d-cab5-481b-887a-78611fa00bff
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Howarth, P.H., Wilson, J., Djukanovic, R., Wilson, S.J., Britten, K., Walls, A.F., Roche, W.R. and Holgate, S.T. (1991) Airway inflammation and atopic asthma: a comparative bronchoscopic investigation. International Archives of Allergy and Immunology, 94 (1-4), 266-269. (doi:10.1159/000235379). (PMID:1937887)

Record type: Article

Abstract

Flexible fibre-optic bronchoscopy under local anaesthesia has been used to investigate the cellular airway events in atopic asthma. The findings have been compared to those from atopic individuals without asthma and non-atopic healthy controls, in an attempt to discern those changes relevant to clinical disease expression. Immunohistochemical and electron-microscopic analyses of airway biopsies identified that an atopic diathesis is associated with tissue eosinophil infiltration and mast cell degranulation. The eosinophilia was greatest in those atopic individuals with asthma. Flow-cytometric analysis of airway lavage revealed significantly enhanced T lymphocyte activation in clinical asthma. These findings are consistent with the hypothesis that T lymphocyte activation, through cytokine release, amplifies the tissue eosinophilia in asthma and that this combination is associated with clinical disease expression.

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Published date: 1991

Identifiers

Local EPrints ID: 190997
URI: https://eprints.soton.ac.uk/id/eprint/190997
ISSN: 1018-2438
PURE UUID: 059fc8a8-1f91-42d7-9433-27ad18b9fbcb
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

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Date deposited: 20 Jun 2011 14:12
Last modified: 30 Jun 2018 00:36

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