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Airway inflammation and atopic asthma: a comparative bronchoscopic investigation

Record type: Article

Flexible fibre-optic bronchoscopy under local anaesthesia has been used to investigate the cellular airway events in atopic asthma. The findings have been compared to those from atopic individuals without asthma and non-atopic healthy controls, in an attempt to discern those changes relevant to clinical disease expression. Immunohistochemical and electron-microscopic analyses of airway biopsies identified that an atopic diathesis is associated with tissue eosinophil infiltration and mast cell degranulation. The eosinophilia was greatest in those atopic individuals with asthma. Flow-cytometric analysis of airway lavage revealed significantly enhanced T lymphocyte activation in clinical asthma. These findings are consistent with the hypothesis that T lymphocyte activation, through cytokine release, amplifies the tissue eosinophilia in asthma and that this combination is associated with clinical disease expression.

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Citation

Howarth, P.H., Wilson, J., Djukanovic, R., Wilson, S.J., Britten, K., Walls, A.F., Roche, W.R. and Holgate, S.T. (1991) Airway inflammation and atopic asthma: a comparative bronchoscopic investigation International Archives of Allergy and Immunology, 94, (1-4), pp. 266-269. (doi:10.1159/000235379). (PMID:1937887).

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Published date: 1991

Identifiers

Local EPrints ID: 190997
URI: http://eprints.soton.ac.uk/id/eprint/190997
ISSN: 1018-2438
PURE UUID: 059fc8a8-1f91-42d7-9433-27ad18b9fbcb
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

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Date deposited: 20 Jun 2011 14:12
Last modified: 18 Jul 2017 11:36

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Contributors

Author: P.H. Howarth
Author: J. Wilson
Author: R. Djukanovic ORCID iD
Author: S.J. Wilson
Author: K. Britten
Author: A.F. Walls
Author: W.R. Roche
Author: S.T. Holgate

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