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Mucosal inflammation in severe glucocorticoid-dependent asthma

Record type: Article

To improve our understanding of the inflammatory mechanisms underlying severe disease, a biopsy study was performed comparing 15 clinically unstable glucocorticoid-dependent asthmatics, 10 mild asthmatics, and 10 control subjects. Compared with mild asthma, severe asthma was characterized by reduced mucosal eosinophilia. Whilst no significant differences were found in the numbers of mast cells, neutrophils, CD3+ and CD4+ T-cells between the three groups, up to a 4-fold increase In the numbers of activated T-lymphocytes bearing the interleukin (IL)-2 receptor (IL-2R) was found in the mucosa in severe asthma compared to mild asthma (p = 0.03) and control subjects (p = 0.003). Compared to control subjects, the mucosa of severe asthmatics contained significantly (p = 0.02) higher numbers of IL-5+ cells, with no differences between mild and severe disease. In contrast, staining for the anti-IL-4 monoclonal antibody 3H4 revealed that biopsies from mild asthmatics contained more IL4+ cells than biopsies from severe asthmatics and control subjects (p = 0.0008). In the severe asthmatics, a close correlation (r(s) = 0.76, p = 0.005) was found between the numbers of IL-2R-bearing cells and the variability in peak expiratory flow. In conclusion, persistent T-cell activation is a prominent feature of severe asthma. These results also indicate that interleukin-5, and not interleukin-4, is upregulated in severe disease.

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Citation

Vrugt, B., Wilson, S.J., Underwood, J., Bron, A., de Bruyn, R., Bradding, P., Holgate, S.T., Djukanovic, R. and Aalbers, R. (1999) Mucosal inflammation in severe glucocorticoid-dependent asthma European Respiratory Journal, 13, (6), pp. 1245-1252. (PMID:10445597).

More information

Published date: June 1999

Identifiers

Local EPrints ID: 191005
URI: http://eprints.soton.ac.uk/id/eprint/191005
ISSN: 0903-1936
PURE UUID: 63fe6f3b-7e95-4730-966b-d3328d3f23c8
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

Catalogue record

Date deposited: 20 Jun 2011 15:44
Last modified: 18 Jul 2017 11:36

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Contributors

Author: B. Vrugt
Author: S.J. Wilson
Author: J. Underwood
Author: A. Bron
Author: R. de Bruyn
Author: P. Bradding
Author: S.T. Holgate
Author: R. Djukanovic ORCID iD
Author: R. Aalbers

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