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Markers of inflammatory status associated with hearing threshold in older people: findings from the Herfordshire ageing study

Record type: Article

Background: age-related hearing loss is a common disabling condition but it causes are not well understood and the role of inflammation as an influencing factor has received little consideration in the literature.

Objective: to investigate the association between inflammatory markers and hearing in community dwelling older men and women.

Design: cross-sectional analysis within a cohort study.

Setting: the Hertfordshire Ageing Study.
Participants: 343 men and 268 women aged 63 to 74 years on whom data on audiometric testing, inflammatory markers and covariates were available at follow-up in 1995.

Main outcome measures: average hearing threshold level (across 500 to 4000 Hz) of the worst hearing ear and audiometric slope in dB/octave from 500 to 4000Hz.
Results: older age, smoking, history of noise exposure and male gender (all p<0.001) were associated with higher mean hearing threshold in the worse ear in univariate analysis. After adjustment for these factors in multiple regression models, four measures of immune or inflammatory status were significantly associated with hearing threshold, namely white blood cell count (r=0.13,p=0.001), neutrophil count (r=0.13,p=0.002), IL-6 (r=0.10,p=0.05) and CRP (r=0.11,p=0.01). None of the inflammatory markers were associated with maximum audiometric slope in adjusted analyses.

Conclusions: markers of inflammatory status were significantly associated with degree of hearing loss in older people. The findings are consistent with the possibility that inflammatory changes occurring with ageing may be involved in age-related hearing loss. Longitudinal data would enable this hypothesis to be explored further

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Citation

Verschuur, C.A., Dowell, Aphra, Syddall, H.E., Ntani, Georgia, Simmonds, S.J., Baylis, D., Gale, C.R., Walsh, B., Cooper, Cyrus, Lord, Janet M. and Sayer, A.A. (2012) Markers of inflammatory status associated with hearing threshold in older people: findings from the Herfordshire ageing study Age and Ageing, 41, (1), pp. 92-97. (doi:10.1093/ageing/afr140).

More information

e-pub ahead of print date: 14 November 2011
Published date: January 2012
Keywords: hearing, age-related hearing loss, presbycusis, inflamation, ageing, older people, elderly
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 191217
URI: http://eprints.soton.ac.uk/id/eprint/191217
ISSN: 0002-0729
PURE UUID: 68da31e1-e467-433c-a089-b26587c30e3c
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for B. Walsh: ORCID iD orcid.org/0000-0003-1008-0545

Catalogue record

Date deposited: 17 Jun 2011 12:32
Last modified: 18 Jul 2017 11:35

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Contributors

Author: C.A. Verschuur
Author: Aphra Dowell
Author: H.E. Syddall ORCID iD
Author: Georgia Ntani
Author: S.J. Simmonds
Author: D. Baylis
Author: C.R. Gale
Author: B. Walsh ORCID iD
Author: Cyrus Cooper
Author: Janet M. Lord
Author: A.A. Sayer

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