Directed formation of DNA nanoarrays through orthogonal self-assembly

Burns, Jonathan R., Zekonyte, Jurgita, Siligardi, Giuliano, Hussain, Rohanah and Stulz, Eugen (2011) Directed formation of DNA nanoarrays through orthogonal self-assembly Molecules, 16, (6), pp. 4912-4922. (doi:10.3390/molecules16064912). (PMID:21677604).


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We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II)and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

Item Type: Article
Digital Object Identifier (DOI): doi:10.3390/molecules16064912
Keywords: terpy-dna, afm, tem, dna nanotubes

ePrint ID: 191665
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Date Event
Date Deposited: 23 Jun 2011 12:29
Last Modified: 18 Apr 2017 01:54
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