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Directed formation of DNA nanoarrays through orthogonal self-assembly

Directed formation of DNA nanoarrays through orthogonal self-assembly
Directed formation of DNA nanoarrays through orthogonal self-assembly
We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II)and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
terpy-dna, afm, tem, dna nanotubes
4912-4922
Burns, Jonathan R.
648a50f5-bcca-4989-8de3-60cc582b7ed9
Zekonyte, Jurgita
c40df725-5ce3-4692-b638-bbb4d847b5ea
Siligardi, Giuliano
ebce490a-2faa-4b98-9703-ae0d6f8e46c2
Hussain, Rohanah
d46302e5-4734-4f59-9ac1-bc7b1f62693c
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Burns, Jonathan R.
648a50f5-bcca-4989-8de3-60cc582b7ed9
Zekonyte, Jurgita
c40df725-5ce3-4692-b638-bbb4d847b5ea
Siligardi, Giuliano
ebce490a-2faa-4b98-9703-ae0d6f8e46c2
Hussain, Rohanah
d46302e5-4734-4f59-9ac1-bc7b1f62693c
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d

Burns, Jonathan R., Zekonyte, Jurgita, Siligardi, Giuliano, Hussain, Rohanah and Stulz, Eugen (2011) Directed formation of DNA nanoarrays through orthogonal self-assembly. Molecules, 16 (6), 4912-4922. (doi:10.3390/molecules16064912). (PMID:21677604)

Record type: Article

Abstract

We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II)and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

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Published date: 2011
Keywords: terpy-dna, afm, tem, dna nanotubes

Identifiers

Local EPrints ID: 191665
URI: https://eprints.soton.ac.uk/id/eprint/191665
PURE UUID: c65bb474-968d-4687-87c7-e5bb5f7390ee
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

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Date deposited: 23 Jun 2011 12:29
Last modified: 12 Nov 2019 01:46

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