The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection
The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection
There is a particular need for an effective vaccine against life-threatening meningitis and septicemia caused by Neisseria meningitidis (meningococcus) serogroup B strains. Vaccine strategies incorporating capsular polysaccharide have proved effective against other meningococcal serogroups, but are not applicable to serogroup B. Attention has therefore focused on the subcapsular outer membrane protein antigens as potential vaccine components. The sequencing of genomes from three serogroups and the availability of the corresponding translated protein databases, combined with the development of sensitive proteomic techniques, have opened up new avenues of meningococcal vaccine research. This has resulted in the identification of potential candidate antigens for incorporation into multicomponent meningococcal vaccines.
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Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
Williams, Jeanette N.
b8cee39f-8709-40ac-84ad-e62e3c1c7d8e
22 July 2010
Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
Williams, Jeanette N.
b8cee39f-8709-40ac-84ad-e62e3c1c7d8e
Heckels, John E. and Williams, Jeanette N.
(2010)
The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection.
Genome Medicine, 2 (7), .
(doi:10.1186/gm164).
(PMID:20670394)
Abstract
There is a particular need for an effective vaccine against life-threatening meningitis and septicemia caused by Neisseria meningitidis (meningococcus) serogroup B strains. Vaccine strategies incorporating capsular polysaccharide have proved effective against other meningococcal serogroups, but are not applicable to serogroup B. Attention has therefore focused on the subcapsular outer membrane protein antigens as potential vaccine components. The sequencing of genomes from three serogroups and the availability of the corresponding translated protein databases, combined with the development of sensitive proteomic techniques, have opened up new avenues of meningococcal vaccine research. This has resulted in the identification of potential candidate antigens for incorporation into multicomponent meningococcal vaccines.
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Published date: 22 July 2010
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Local EPrints ID: 192097
URI: http://eprints.soton.ac.uk/id/eprint/192097
PURE UUID: 54e6ddbe-6d2c-4ea1-820c-db99eae5a303
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Date deposited: 29 Jun 2011 13:54
Last modified: 14 Mar 2024 03:48
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Jeanette N. Williams
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