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Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats

Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats
Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats
Fish oil (FO) is widely known by its capacity to positively modulate immune parameters and decrease the growth of some tumors. Despite the enormous number of studies addressing the effects of FO, there are few reports showing similar results using other marine sources of lipid compounds with biologic importance. This study aimed to compare the effects of shark liver oil (SLO), which is a source of omega-3 fatty acids and alkylglycerols, with those obtained with FO administration, or the association of both, on tumor growth and the innate immune system in Walker-256 tumor–bearing rats. Beginning at 21 days of age, Wistar rats were fed regular chow and/or FO and/or SLO supplement (1 g/kg body weight per day) for 14 weeks. Walker-256 tumor cells were inoculated on the 90th day. As expected, 14 days after inoculation, rats fed with FO presented tumor weights that were 50% lower than the control tumors (P < .05). The association of both FO and SLO and ingestion of SLO alone also reached the same reduction level. Except for adhesion, all macrophage parameters assayed were 200% higher in rats fed with FO and those supplemented with both FO and SLO compared with control rats. Only reactive nitrogen species production was increased by SLO. These results suggest that SLO might also have indirect antitumor properties. Conversely, there were no additive effects when SLO was administered with FO. Therefore, SLO is another marine compound with in vivo antitumor effects, but its action mechanisms seem not to be related to major modifications on macrophage function.

wistar rats, shark liver oil, fish oil, tumor cells, macrophages, cancer
0271-5317
770-776
Belo, Sérgio R.B.
3b7d31d8-c37b-4315-b6f2-2b2945190ef6
Lagher, Fabíola
783bdb40-5619-4141-9143-04d2cc32ce0e
Bonatto, Sandro J.
b3b10b9b-922e-4c04-b007-c7863e283574
Naliwaiko, Katya
6be7df1b-6612-43c9-849f-d1e760337d9d
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Nunes, Everson A.
62a7f5db-40d7-4814-a1d0-2c1eb71a9c29
Fernandes, Luiz C.
380a7161-4e23-40d3-afde-7cc36ec65060
Belo, Sérgio R.B.
3b7d31d8-c37b-4315-b6f2-2b2945190ef6
Lagher, Fabíola
783bdb40-5619-4141-9143-04d2cc32ce0e
Bonatto, Sandro J.
b3b10b9b-922e-4c04-b007-c7863e283574
Naliwaiko, Katya
6be7df1b-6612-43c9-849f-d1e760337d9d
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Nunes, Everson A.
62a7f5db-40d7-4814-a1d0-2c1eb71a9c29
Fernandes, Luiz C.
380a7161-4e23-40d3-afde-7cc36ec65060

Belo, Sérgio R.B., Lagher, Fabíola, Bonatto, Sandro J., Naliwaiko, Katya, Calder, Philip C., Nunes, Everson A. and Fernandes, Luiz C. (2010) Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats. Nutrition Research, 30 (11), 770-776. (doi:10.1016/j.nutres.2010.09.015).

Record type: Article

Abstract

Fish oil (FO) is widely known by its capacity to positively modulate immune parameters and decrease the growth of some tumors. Despite the enormous number of studies addressing the effects of FO, there are few reports showing similar results using other marine sources of lipid compounds with biologic importance. This study aimed to compare the effects of shark liver oil (SLO), which is a source of omega-3 fatty acids and alkylglycerols, with those obtained with FO administration, or the association of both, on tumor growth and the innate immune system in Walker-256 tumor–bearing rats. Beginning at 21 days of age, Wistar rats were fed regular chow and/or FO and/or SLO supplement (1 g/kg body weight per day) for 14 weeks. Walker-256 tumor cells were inoculated on the 90th day. As expected, 14 days after inoculation, rats fed with FO presented tumor weights that were 50% lower than the control tumors (P < .05). The association of both FO and SLO and ingestion of SLO alone also reached the same reduction level. Except for adhesion, all macrophage parameters assayed were 200% higher in rats fed with FO and those supplemented with both FO and SLO compared with control rats. Only reactive nitrogen species production was increased by SLO. These results suggest that SLO might also have indirect antitumor properties. Conversely, there were no additive effects when SLO was administered with FO. Therefore, SLO is another marine compound with in vivo antitumor effects, but its action mechanisms seem not to be related to major modifications on macrophage function.

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More information

Published date: November 2010
Keywords: wistar rats, shark liver oil, fish oil, tumor cells, macrophages, cancer

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Local EPrints ID: 192101
URI: https://eprints.soton.ac.uk/id/eprint/192101
ISSN: 0271-5317
PURE UUID: 894bd68a-247f-40fd-a1e6-11a5b764a2a9

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Date deposited: 29 Jun 2011 14:18
Last modified: 18 Jul 2017 11:32

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Contributors

Author: Sérgio R.B. Belo
Author: Fabíola Lagher
Author: Sandro J. Bonatto
Author: Katya Naliwaiko
Author: Everson A. Nunes
Author: Luiz C. Fernandes

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