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Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms

Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D. and Hanson, Mark A. (2011) Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms Progress in Biophysics and Molecular Biology, 106, (1), pp. 272-280. (PMID:21219925 ).

Record type: Article


There is now evidence that developmental influences have lifelong effects on cardiovascular and metabolic function and that elements of the heritable or familial component of susceptibility to cardiovascular disease, obesity and other non-communicable diseases (NCD) can be transmitted across generations by non-genomic means. In animals the developmental environment induces altered phenotypes through genetic, physiological (especially endocrine) and epigenetic mechanisms. The latter include DNA methylation, covalent modifications of histones and non-coding RNAs. Such ‘tuning’ of phenotype has potential adaptive value and may confer Darwinian fitness advantage because it either adjusts the phenotype to current circumstances and/or attempts to match an individual’s responses to the environment predicted to be experienced later. When the phenotype is mismatched to the later environment, e.g. from inaccurate nutritional cues from the mother or placenta before birth, or from rapid environmental change through improved socio-economic conditions, risk of NCD increases. Such mechanisms are also thought to play roles in ageing and early onset of puberty, reinforcing a life-course perspective on such adaptive responses, especially the detrimental later effects of trade-offs. Epigenetic changes induced during development are highly gene-specific and function at the level of individual CpG dinucleotides in both gene promoter and intergenic regions. Evidence is accruing that endocrine or nutritional interventions during early postnatal life can reverse epigenetic and phenotypic changes induced, for example, by unbalanced maternal diet during pregnancy. Elucidation of epigenetic processes may permit perinatal identification of individuals most at risk of later NCD and enable early intervention strategies to reduce such risk.

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Published date: July 2011
Keywords: non-communicable disease, nutrition, developmental plasticity, epigenetics
Organisations: Human Development & Health


Local EPrints ID: 192457
ISSN: 0079-6107
PURE UUID: dcdfcbc0-db41-47ac-b02b-e17053ba67f6
ORCID for Keith M. Godfrey: ORCID iD
ORCID for Karen A. Lillycrop: ORCID iD
ORCID for Graham C. Burdge: ORCID iD

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Date deposited: 04 Jul 2011 15:02
Last modified: 28 Aug 2017 18:52

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Author: Peter D. Gluckman
Author: Mark A. Hanson

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