Tissue factor: biological function and clinical significance
Tissue factor: biological function and clinical significance
Tissue Factor is the principal cellular initiator of normal blood coagulation. It is frequently encrypted in the plasma membrane of cells in contact with blood, but under certain pathological conditions endothelial cells, monocytes or macrophages may express tissue factor; and hence trigger coagulation activation. Aberrant expression of tissue factor by these cells is thought to be responsible for the thrombophilia found in septic shock, atherosclerosis and cancer. Tissue factor is produced by tumor-associated macrophages where it is believed to play an important role in tumor growth and dissemination. It may also be involved in other cellular processes such as intracellular signalling, angiogenesis and embryonic blood-vessel development. Tissue factor can be found both as free (soluble tissue factor) and membrane bound forms. Several studies have shown that measurements of any of these forms may provided clinically significant information, particularly in patients with malignant and inflammatory diseases, and are cost-effective.
tissue factor, forms, assays clinical importance, review
135-143
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
2002
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Lwaleed, Bashir A.
(2002)
Tissue factor: biological function and clinical significance.
Saudi Medical Journal, 23 (2), .
Abstract
Tissue Factor is the principal cellular initiator of normal blood coagulation. It is frequently encrypted in the plasma membrane of cells in contact with blood, but under certain pathological conditions endothelial cells, monocytes or macrophages may express tissue factor; and hence trigger coagulation activation. Aberrant expression of tissue factor by these cells is thought to be responsible for the thrombophilia found in septic shock, atherosclerosis and cancer. Tissue factor is produced by tumor-associated macrophages where it is believed to play an important role in tumor growth and dissemination. It may also be involved in other cellular processes such as intracellular signalling, angiogenesis and embryonic blood-vessel development. Tissue factor can be found both as free (soluble tissue factor) and membrane bound forms. Several studies have shown that measurements of any of these forms may provided clinically significant information, particularly in patients with malignant and inflammatory diseases, and are cost-effective.
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Published date: 2002
Keywords:
tissue factor, forms, assays clinical importance, review
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Local EPrints ID: 19254
URI: http://eprints.soton.ac.uk/id/eprint/19254
PURE UUID: af49d54b-d198-49df-86e3-e6355f48491b
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Date deposited: 01 Feb 2006
Last modified: 06 Aug 2024 01:39
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