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Widespread morphoea following radiotherapy for carcinoma of the breast

Widespread morphoea following radiotherapy for carcinoma of the breast
Widespread morphoea following radiotherapy for carcinoma of the breast
We report a case of a 60-year-old lady who was treated with radiotherapy for breast cancer of both breasts 8 years apart. Thirteen years after the first dose of radiotherapy she developed localized morphoea in all the irradiated skin of the chest wall and also the gaiter regions of both lower legs. Radiation-induced localized morphoea has been previously reported; however, there is no previous publication of an occurrence at a distant site as in this case. This case demonstrates that morphoea can occur distant to the original breast carcinoma and site of radiotherapy. We postulate that radiotherapy can induce neoantigen formation, which initiates a T cell response and subsequent tissue growth factor alpha release. Tissue growth factor alpha induces fibroblast activation and collagen production may persist due to a positive feedback mechanism within the fibroblast. The reason why the disease did not generalize remains unclear.
0307-6938
160-162
Ardern-Jones, M.R.
7ac43c24-94ab-4d19-ba69-afaa546bec90
Black, M.M.
81b891b5-1657-4fa3-8ce1-149eb467b5e2
Ardern-Jones, M.R.
7ac43c24-94ab-4d19-ba69-afaa546bec90
Black, M.M.
81b891b5-1657-4fa3-8ce1-149eb467b5e2

Ardern-Jones, M.R. and Black, M.M. (2003) Widespread morphoea following radiotherapy for carcinoma of the breast. Clinical and Experimental Dermatology, 28 (2), 160-162. (doi:10.1046/j.1365-2230.2003.01186.x). (PMID:12653704)

Record type: Article

Abstract

We report a case of a 60-year-old lady who was treated with radiotherapy for breast cancer of both breasts 8 years apart. Thirteen years after the first dose of radiotherapy she developed localized morphoea in all the irradiated skin of the chest wall and also the gaiter regions of both lower legs. Radiation-induced localized morphoea has been previously reported; however, there is no previous publication of an occurrence at a distant site as in this case. This case demonstrates that morphoea can occur distant to the original breast carcinoma and site of radiotherapy. We postulate that radiotherapy can induce neoantigen formation, which initiates a T cell response and subsequent tissue growth factor alpha release. Tissue growth factor alpha induces fibroblast activation and collagen production may persist due to a positive feedback mechanism within the fibroblast. The reason why the disease did not generalize remains unclear.

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Published date: March 2003

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Local EPrints ID: 192735
URI: https://eprints.soton.ac.uk/id/eprint/192735
ISSN: 0307-6938
PURE UUID: 0bada0c9-12f1-4bb3-b045-f6b871d8bf10

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Date deposited: 07 Jul 2011 12:25
Last modified: 16 Jul 2019 23:26

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Author: M.M. Black

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