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Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis

Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis
Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis
Four serosubtypes (P1.7, 16, P1.7-2, 4, P1.19, 15 and P1.5-1, 10-4) of the PorA outer-membrane protein of Neisseria meningitidis were purified as recombinant proteins and incorporated into liposomes to investigate their immunogenicity. Each serosubtype induced high levels of bactericidal activity against the homologous strain. In addition, liposome preparations containing multiple serosubtypes induced high levels of bactericidal activity against each of the four strains. Significantly, antisera raised against monovalent and multivalent liposomes also showed cross-reactive bactericidal activity against heterologous strains. These data demonstrate that multivalent liposome vaccines, containing multiple PorA serosubtypes, have the potential to provide protection against a broad range of meningococcal strains
36-44
Humphries, Holly E.
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Williams, Jeanette N.
b8cee39f-8709-40ac-84ad-e62e3c1c7d8e
Blackstone, Ramona
1c25f1d0-c3ce-45c6-9dc4-3cfaa70cd037
Jolley, Keith A.
4ae51ae9-7a80-4ce0-a61c-1828b602d2ac
Yuen, Ho M.
b1df4c57-0c2a-44ac-ab40-22b88e8effe8
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
Humphries, Holly E.
dfbfbf86-71b7-4a11-8192-0afd0eb817a6
Williams, Jeanette N.
b8cee39f-8709-40ac-84ad-e62e3c1c7d8e
Blackstone, Ramona
1c25f1d0-c3ce-45c6-9dc4-3cfaa70cd037
Jolley, Keith A.
4ae51ae9-7a80-4ce0-a61c-1828b602d2ac
Yuen, Ho M.
b1df4c57-0c2a-44ac-ab40-22b88e8effe8
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31

Humphries, Holly E., Williams, Jeanette N., Blackstone, Ramona, Jolley, Keith A., Yuen, Ho M., Christodoulides, Myron and Heckels, John E. (2006) Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis. Vaccine, 24 (1), 36-44. (doi:10.1016/j.vaccine.2005.07.056). (PMID:16105711)

Record type: Article

Abstract

Four serosubtypes (P1.7, 16, P1.7-2, 4, P1.19, 15 and P1.5-1, 10-4) of the PorA outer-membrane protein of Neisseria meningitidis were purified as recombinant proteins and incorporated into liposomes to investigate their immunogenicity. Each serosubtype induced high levels of bactericidal activity against the homologous strain. In addition, liposome preparations containing multiple serosubtypes induced high levels of bactericidal activity against each of the four strains. Significantly, antisera raised against monovalent and multivalent liposomes also showed cross-reactive bactericidal activity against heterologous strains. These data demonstrate that multivalent liposome vaccines, containing multiple PorA serosubtypes, have the potential to provide protection against a broad range of meningococcal strains

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More information

Published date: 9 January 2006
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 192769
URI: http://eprints.soton.ac.uk/id/eprint/192769
PURE UUID: 11b38dd3-9f5f-44a4-af31-dc0c7449273b

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Date deposited: 08 Jul 2011 07:36
Last modified: 16 Jul 2019 23:26

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