Cardiovascular variability during treatment with haloperidol, olanzapine or risperidone in recent-onset schizophrenia
Cardiovascular variability during treatment with haloperidol, olanzapine or risperidone in recent-onset schizophrenia
This study aimed to investigate the effects of treatment with haloperidol, olanzapine and risperidone on cardiovascular variability in patients with recent-onset schizophrenia by means of spectral analysis. Unmedicated patients (n = 18) had a higher mean heart rate and a tendency for a lower high-frequency power of heart rate variability than healthy control subjects (n = 57), indicating a decreased cardiac vagal control in unmedicated patients with schizophrenia. Patients treated with haloperidol (n = 10) showed significantly lower low-frequency power of heart rate and systolic blood pressure variability compared with olanzapine-treated patients, suggesting that haloperidol attenuated sympathetic functioning. On the contrary, olanzapine-treated patients (n = 10) showed the highest power in the low-frequency range of heart rate and systolic blood pressure variability, suggesting an increased sympathetic cardiac functioning. No significant effects of risperidone (n = 13) were found. None of the antipsychotic agents differed in their parasympathetic cardiovascular effects. We conclude that young, unmedicated patients with schizophrenia differed from controls in their parasympathetic functioning, but the antipsychotic agents haloperidol, risperidone and olanzapine induced only minor cardiovascular side effects
antipsychotics, autonomic nervous system, baroreflex sensitivity, cardiovascular functioning, heart rate variability, schizophrenia, spectral analysis
697-707
Hempel, R.J.
2dfa9856-74dd-49b5-86e6-f78eace6727f
Tulen, J.H.M.
481be9ce-2d8f-4122-92e2-caa3ba5c6b32
van Beveren, N.J.M.
d4e6c5e3-4f11-4951-b248-a9c606616d2d
Roder, C.H.
436b43fd-3063-4c30-a59e-b887f40a4639
Hengeveld, M.W.
e1c9e509-0a59-457d-b745-c663608bf5fd
August 2009
Hempel, R.J.
2dfa9856-74dd-49b5-86e6-f78eace6727f
Tulen, J.H.M.
481be9ce-2d8f-4122-92e2-caa3ba5c6b32
van Beveren, N.J.M.
d4e6c5e3-4f11-4951-b248-a9c606616d2d
Roder, C.H.
436b43fd-3063-4c30-a59e-b887f40a4639
Hengeveld, M.W.
e1c9e509-0a59-457d-b745-c663608bf5fd
Hempel, R.J., Tulen, J.H.M., van Beveren, N.J.M., Roder, C.H. and Hengeveld, M.W.
(2009)
Cardiovascular variability during treatment with haloperidol, olanzapine or risperidone in recent-onset schizophrenia.
Journal of Psychopharmacology, 23 (6), .
(doi:10.1177/0269881108091254).
(PMID:18562420)
Abstract
This study aimed to investigate the effects of treatment with haloperidol, olanzapine and risperidone on cardiovascular variability in patients with recent-onset schizophrenia by means of spectral analysis. Unmedicated patients (n = 18) had a higher mean heart rate and a tendency for a lower high-frequency power of heart rate variability than healthy control subjects (n = 57), indicating a decreased cardiac vagal control in unmedicated patients with schizophrenia. Patients treated with haloperidol (n = 10) showed significantly lower low-frequency power of heart rate and systolic blood pressure variability compared with olanzapine-treated patients, suggesting that haloperidol attenuated sympathetic functioning. On the contrary, olanzapine-treated patients (n = 10) showed the highest power in the low-frequency range of heart rate and systolic blood pressure variability, suggesting an increased sympathetic cardiac functioning. No significant effects of risperidone (n = 13) were found. None of the antipsychotic agents differed in their parasympathetic cardiovascular effects. We conclude that young, unmedicated patients with schizophrenia differed from controls in their parasympathetic functioning, but the antipsychotic agents haloperidol, risperidone and olanzapine induced only minor cardiovascular side effects
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Published date: August 2009
Keywords:
antipsychotics, autonomic nervous system, baroreflex sensitivity, cardiovascular functioning, heart rate variability, schizophrenia, spectral analysis
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Local EPrints ID: 193009
URI: http://eprints.soton.ac.uk/id/eprint/193009
ISSN: 0269-8811
PURE UUID: dbb91877-c115-451f-8588-97a77edbdeb8
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Date deposited: 11 Jul 2011 11:59
Last modified: 14 Mar 2024 03:53
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Author:
R.J. Hempel
Author:
J.H.M. Tulen
Author:
N.J.M. van Beveren
Author:
C.H. Roder
Author:
M.W. Hengeveld
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