The biology and tumour-related properties of monocyte tissue factor
The biology and tumour-related properties of monocyte tissue factor
Tissue factor (TF, coagulation factor III, CD142) is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. TF is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. It can exist encrypted and unavailable functionally in the plasma membrane and the appearance of functional TF may be due to synthesis and/or de-encryption. Inflammatory cells often express TF and act to induce its production or de-encryption by other cells locally and, apparently, at remote sites. Inappropriate expression of TF by endothelial cells, macrophages or monocytes is thought to be an important trigger of coagulation in various pathological conditions. Several studies have shown that measurements of monocyte TF (mTF) may provide clinically significant information, particularly in patients with malignant and inflammatory diseases.
tissue factor, tumour biology, monocyte tissue factor, causes of expression, clinical significance, review
3-12
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Bass, P.S.
8498593e-3539-4908-80da-e2606153869a
Cooper, A.J.
8a21c297-eda3-4479-8e81-1de258c8e2a1
2001
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Bass, P.S.
8498593e-3539-4908-80da-e2606153869a
Cooper, A.J.
8a21c297-eda3-4479-8e81-1de258c8e2a1
Lwaleed, B.A., Bass, P.S. and Cooper, A.J.
(2001)
The biology and tumour-related properties of monocyte tissue factor.
The Journal of Pathology, 193 (1), .
(doi:10.1002/1096-9896(2000)9999:9999).
Abstract
Tissue factor (TF, coagulation factor III, CD142) is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. TF is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. It can exist encrypted and unavailable functionally in the plasma membrane and the appearance of functional TF may be due to synthesis and/or de-encryption. Inflammatory cells often express TF and act to induce its production or de-encryption by other cells locally and, apparently, at remote sites. Inappropriate expression of TF by endothelial cells, macrophages or monocytes is thought to be an important trigger of coagulation in various pathological conditions. Several studies have shown that measurements of monocyte TF (mTF) may provide clinically significant information, particularly in patients with malignant and inflammatory diseases.
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Published date: 2001
Keywords:
tissue factor, tumour biology, monocyte tissue factor, causes of expression, clinical significance, review
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Local EPrints ID: 19303
URI: http://eprints.soton.ac.uk/id/eprint/19303
ISSN: 1096-9896
PURE UUID: a4c1549d-8648-4c4b-b0e7-2230ffce70af
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Date deposited: 01 Feb 2006
Last modified: 06 Aug 2024 01:39
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Author:
P.S. Bass
Author:
A.J. Cooper
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