The clinical value of measuring tissue factor activity in patients with cancer
The clinical value of measuring tissue factor activity in patients with cancer
The association between cancer and thromboembolic disease is well known. This relationship is complex and in many, perhaps most, malignant diseases acts through multiple pathways. Increased tissue factor expression by endothelial cells, monocytes or macrophages has been implicated as one of these pathways. As well as being found in the circulating blood, tissue factor is also found in urine in a lipid-associated form. Although urinary tissue factor might be independent from that found in the circulation, its levels may reflect the status of peripheral blood monocyte activation. Thus, measurements of monocyte and/or urinary tissue factor may be of clinical significance, particularly in cancer, where levels could be valuable for diagnosis and monitoring progression.
tissue factor, cancer, thromboembolic disease, measuring tissue factor activity, clinical value
521-522
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
2002
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Lwaleed, B.A.
(2002)
The clinical value of measuring tissue factor activity in patients with cancer.
Medical Hypotheses, 58 (6), .
(doi:10.1054/mehy.2001.1502).
Abstract
The association between cancer and thromboembolic disease is well known. This relationship is complex and in many, perhaps most, malignant diseases acts through multiple pathways. Increased tissue factor expression by endothelial cells, monocytes or macrophages has been implicated as one of these pathways. As well as being found in the circulating blood, tissue factor is also found in urine in a lipid-associated form. Although urinary tissue factor might be independent from that found in the circulation, its levels may reflect the status of peripheral blood monocyte activation. Thus, measurements of monocyte and/or urinary tissue factor may be of clinical significance, particularly in cancer, where levels could be valuable for diagnosis and monitoring progression.
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Published date: 2002
Keywords:
tissue factor, cancer, thromboembolic disease, measuring tissue factor activity, clinical value
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Local EPrints ID: 19308
URI: http://eprints.soton.ac.uk/id/eprint/19308
ISSN: 0306-9877
PURE UUID: 1e03fdf4-28c6-40ea-8f37-cbfc100b9e7b
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Date deposited: 01 Feb 2006
Last modified: 06 Aug 2024 01:39
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