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Lack of immunity in university students before an outbreak of serogroup C meningococcal infection

Record type: Article

Immunity to meningococci was determined in infected and uninfected students before and during an outbreak of serogroup C meningococcal infection at a university in the United Kingdom. No immunity against the outbreak strain was detected in serum taken from infected students prior to the outbreak or at the time of admission; bactericidal activity developed during convalescence. Carriage of all strains of serogroup C meningococci in asymptomatic students was low (0.9%), and no carriage of the outbreak strain could be detected. Immunity in the at-risk student population before the outbreak was low: 90% of students had no significant bactericidal activity against the outbreak strain. A low prevalence of carriage of the outbreak strain, together with a low prevalence of protective immunity within the student population, was associated with a high incidence of invasive disease in those who acquired the outbreak strain.

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Citation

Jones, Graeme R., Williams, Jeanette N., Christodoulides, Myron, Jolley, Keith and Heckels, John E. (2000) Lack of immunity in university students before an outbreak of serogroup C meningococcal infection The Journal of Infectious Diseases, 181, (3), pp. 1172-1175. (doi:10.1086/315352). (PMID:10720549).

More information

Published date: March 2000
Organisations: Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 193807
URI: http://eprints.soton.ac.uk/id/eprint/193807
ISSN: 0022-1899
PURE UUID: a8321529-cdb2-4f35-afce-be3ac3667b00

Catalogue record

Date deposited: 20 Jul 2011 13:24
Last modified: 18 Jul 2017 11:28

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Contributors

Author: Graeme R. Jones
Author: Jeanette N. Williams
Author: Keith Jolley
Author: John E. Heckels

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