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Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin

Record type: Article

A variety of adjuvants with the potential for use with experimental human vaccines were used for immunisation of mice, in an attempt to augment the humoral immune response to a multiple antigen peptide (MAP) containing a protective epitope from the sero-subtype specific class 1 porin protein of Neisseria meningitidis, in tandem with a Th-cell epitope. Surface plasmon resonance showed that combinations of the immunomodulators pluronic block co-polymer, muramyl dipeptide and monophosphoryl lipid A (MPL), increased the magnitude and avidity of the immune response in comparison with both Al(OH)3 and Freund-type adjuvants. In addition, the incorporation of MPL was essential for the induction of a broad distribution of antibody isotypes. The antibodies induced recognised the native protein in meningococcal outer membranes in a subtype-specific manner. The formulations containing these multiple immunomodulators which have already been used in human phase I/II trials with experimental vaccines, are candidates for inclusion in future human vaccines based on synthetic peptides containing defined, protective epitopes.

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Citation

Christodoulides, Myron, Rattue, Elizabeth and Heckels, John E. (1999) Effect of adjuvant composition on immune response to a multiple antigen peptide (MAP) containing a protective epitope from Neisseria meningitidis class 1 porin Vaccine, 18, (1-2), pp. 131-9. (doi:10.1016/S0264-410X(99)00190-5). (PMID:10501243).

More information

Published date: 20 August 1999
Keywords: meningococci, adjuvant, peptide vaccine

Identifiers

Local EPrints ID: 193813
URI: http://eprints.soton.ac.uk/id/eprint/193813
PURE UUID: 47c81e19-c82c-4d0f-b3bc-f60b5d4f4285

Catalogue record

Date deposited: 20 Jul 2011 13:38
Last modified: 18 Jul 2017 11:28

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