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Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization

Record type: Article

Meningococcal carriage and the immune response to colonization were studied in a group of military recruits undergoing basic training. Subtyping by determination of the class 1 protein sequence clearly differentiated between strains and demonstrated the dynamics of carriage and transmission. Expression of class 1 protein by each strain remained stable during prolonged carriage by different subjects. Following colonization, a marked increase in serum bactericidal response occurred, which was specific for the subtype of the acquired strain and was associated with an increase in reactivity by Western blot to the homologous class 1 protein. Subjects colonized by multiple strains showed evidence of a specific immune response to the class 1 protein of each strain acquired. The subtype specificity of the bactericidal response to meningococci and the stability of expression of the class 1 protein have important implications for the design of vaccines for prevention of serogroup B meningococcal disease.

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Citation

Jones, Graeme R., Christodoulides, M, Brooks, J, Miller, A, Cartwright, K A and Heckels, John E. (1998) Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization The Journal of Infectious Diseases, 178, (2), pp. 451-459. (PMID:9697726).

More information

Published date: August 1998
Organisations: Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 193817
URI: http://eprints.soton.ac.uk/id/eprint/193817
ISSN: 0022-1899
PURE UUID: 90f7c552-966e-4214-b2b4-3a5d4b0342a6

Catalogue record

Date deposited: 20 Jul 2011 13:46
Last modified: 18 Jul 2017 11:28

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Contributors

Author: Graeme R. Jones
Author: J Brooks
Author: A Miller
Author: K A Cartwright
Author: John E. Heckels

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