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Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder

Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder
Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder
Opiate dependence (OD) and borderline personality disorder (BPD), separately and together, are significant public health problems with poor treatment outcomes. BPD is associated with difficulties in emotion regulation, and brain-imaging studies in BPD individuals indicate differential activation in prefrontal cingulate cortices and their interactions with limbic regions. Likewise, a similar network is implicated in drug cue responsivity in substance abusers. The present, preliminary study used functional MRI to examine activation of this network in comorbid OD/BPD participants when engaged in an “oddball” task that required attention to a target in the context of emotionally negative distractors. Twelve male OD/BPD participants and 12 male healthy controls participated. All OD/BPD participants were taking the opiate replacement medication Suboxone, and a subset of participants was positive for substances of abuse on scan day. Relative to controls, OD/BPD participants demonstrated reduced activation to negative stimuli in the amygdala and anterior cingulate. Unlike previous studies that demonstrated hyperresponsivity in neural regions associated with affective processing in individuals with BPD versus healthy controls, comorbid OD/BPD participants were hyporesponsive to emotional cues. Future studies that also include BPD-only and OD-only groups are necessary to help clarify the individual and potentially synergistic effects of these two conditions.
1949-2715
230-241
Smoski, Moria J.
48abb01e-18fe-49c0-a40a-702d6733a160
Salsman, Nicholas
4ef1cd67-328b-4faa-b6ac-a071f645a82b
Wang, Lihong
387d47ff-f16a-4f83-826a-e66e88fd2a64
Smith, Veronica
546a5419-6eea-43a3-aa94-5bc71b9bb2df
Lynch, Thomas R.
29e90123-0aef-46c8-b320-1617fb48bb20
Dager, Stephen R.
543f43a4-d2a8-4d5c-8d8c-d259ea70f6e9
Labar, Kevin S.
dcaa0f5e-3a73-47d8-b133-cded6a058a3d
Lineham, Marsha M.
3bd89500-35cb-43aa-86fe-08b014df7d8e
Smoski, Moria J.
48abb01e-18fe-49c0-a40a-702d6733a160
Salsman, Nicholas
4ef1cd67-328b-4faa-b6ac-a071f645a82b
Wang, Lihong
387d47ff-f16a-4f83-826a-e66e88fd2a64
Smith, Veronica
546a5419-6eea-43a3-aa94-5bc71b9bb2df
Lynch, Thomas R.
29e90123-0aef-46c8-b320-1617fb48bb20
Dager, Stephen R.
543f43a4-d2a8-4d5c-8d8c-d259ea70f6e9
Labar, Kevin S.
dcaa0f5e-3a73-47d8-b133-cded6a058a3d
Lineham, Marsha M.
3bd89500-35cb-43aa-86fe-08b014df7d8e

Smoski, Moria J., Salsman, Nicholas, Wang, Lihong, Smith, Veronica, Lynch, Thomas R., Dager, Stephen R., Labar, Kevin S. and Lineham, Marsha M. (2011) Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder. Personality Disorders: Theory, Research, and Treatment, 2 (3), 230-241. (doi:10.1037/a0022228).

Record type: Article

Abstract

Opiate dependence (OD) and borderline personality disorder (BPD), separately and together, are significant public health problems with poor treatment outcomes. BPD is associated with difficulties in emotion regulation, and brain-imaging studies in BPD individuals indicate differential activation in prefrontal cingulate cortices and their interactions with limbic regions. Likewise, a similar network is implicated in drug cue responsivity in substance abusers. The present, preliminary study used functional MRI to examine activation of this network in comorbid OD/BPD participants when engaged in an “oddball” task that required attention to a target in the context of emotionally negative distractors. Twelve male OD/BPD participants and 12 male healthy controls participated. All OD/BPD participants were taking the opiate replacement medication Suboxone, and a subset of participants was positive for substances of abuse on scan day. Relative to controls, OD/BPD participants demonstrated reduced activation to negative stimuli in the amygdala and anterior cingulate. Unlike previous studies that demonstrated hyperresponsivity in neural regions associated with affective processing in individuals with BPD versus healthy controls, comorbid OD/BPD participants were hyporesponsive to emotional cues. Future studies that also include BPD-only and OD-only groups are necessary to help clarify the individual and potentially synergistic effects of these two conditions.

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Published date: July 2011

Identifiers

Local EPrints ID: 193969
URI: http://eprints.soton.ac.uk/id/eprint/193969
ISSN: 1949-2715
PURE UUID: f13452ad-6556-4112-83e6-3b73ca2cb76f
ORCID for Thomas R. Lynch: ORCID iD orcid.org/0000-0003-1270-6097

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Date deposited: 22 Jul 2011 09:16
Last modified: 29 Oct 2019 01:45

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