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Solid-phase Friedel-Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones

Record type: Article

Friedel-Crafts acylation with various acyl chlorides of resin-bound 3,4-dimethoxyphenylacetate afforded resin bound ketones which, following treatment with hydrazine, were converted into the corresponding 2,3-benzodiazepines in good yields and purities.

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Citation

Bevacqua, F., Basso, A., Gitto, R., Bradley, M. and Chimirri, A. (2001) Solid-phase Friedel-Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones Tetrahedron Letters, 42, (43), pp. 7683-7685. (doi:10.1016/S0040-4039(01)01602-1).

More information

Published date: 22 October 2001
Keywords: solid-phase synthesis, friedel-crafts acylation, 2, 3-benzodiazepines ampa receptor antagonists

Identifiers

Local EPrints ID: 19406
URI: http://eprints.soton.ac.uk/id/eprint/19406
ISSN: 0040-4039
PURE UUID: 6eaf2594-46a1-4544-89ce-6c7f18b3ceb1

Catalogue record

Date deposited: 14 Feb 2006
Last modified: 17 Jul 2017 16:31

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Contributors

Author: F. Bevacqua
Author: A. Basso
Author: R. Gitto
Author: M. Bradley
Author: A. Chimirri

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