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Synthesis and biological activity of analogues of ptilomycalin A

Black, G. P., Coles, S. J., Hizi, A., Howard-Jones, A. G., Hursthouse, M. B., McGown, A. T., Loya, S., Moore, C. G., Murphy, P. J., Smith, N. K. and Walshe, N. D. A. (2001) Synthesis and biological activity of analogues of ptilomycalin A Tetrahedron Letters, 42, (19), pp. 3377-3381. (doi:10.1016/S0040-4039(01)00400-2).

Record type: Article


Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.

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Published date: 7 May 2001


Local EPrints ID: 19412
ISSN: 0040-4039
PURE UUID: 9114286d-21a2-4a83-8e95-a65a60d61ee0
ORCID for S. J. Coles: ORCID iD

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Date deposited: 14 Feb 2006
Last modified: 17 Jul 2017 16:31

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Author: G. P. Black
Author: S. J. Coles ORCID iD
Author: A. Hizi
Author: A. G. Howard-Jones
Author: A. T. McGown
Author: S. Loya
Author: C. G. Moore
Author: P. J. Murphy
Author: N. K. Smith
Author: N. D. A. Walshe

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