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Synthesis and biological activity of analogues of ptilomycalin A

Synthesis and biological activity of analogues of ptilomycalin A
Synthesis and biological activity of analogues of ptilomycalin A
Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.
0040-4039
3377-3381
Black, G. P.
e8c0586d-4ec6-40bb-a3d9-32bed65de44c
Coles, S. J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Hizi, A.
145d8897-96b3-4b66-b704-0a41f90ad66e
Howard-Jones, A. G.
eb3d3d1d-606c-44f9-8b3e-1c87d8029f62
Hursthouse, M. B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
McGown, A. T.
04a81d38-a2a9-4790-81a6-9e9d3aa611d2
Loya, S.
3d7c6f6b-3e6c-4571-88f2-ac85527a328e
Moore, C. G.
5b34e4ae-1e4c-4f0e-bc1e-bbeb548aa3ec
Murphy, P. J.
e361583b-6b55-4418-a536-24f3405273a2
Smith, N. K.
ab7baf2c-0000-4f13-b654-146b8de04660
Walshe, N. D. A.
be7f840e-ec19-4a8b-b271-032dfa834dab
Black, G. P.
e8c0586d-4ec6-40bb-a3d9-32bed65de44c
Coles, S. J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Hizi, A.
145d8897-96b3-4b66-b704-0a41f90ad66e
Howard-Jones, A. G.
eb3d3d1d-606c-44f9-8b3e-1c87d8029f62
Hursthouse, M. B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
McGown, A. T.
04a81d38-a2a9-4790-81a6-9e9d3aa611d2
Loya, S.
3d7c6f6b-3e6c-4571-88f2-ac85527a328e
Moore, C. G.
5b34e4ae-1e4c-4f0e-bc1e-bbeb548aa3ec
Murphy, P. J.
e361583b-6b55-4418-a536-24f3405273a2
Smith, N. K.
ab7baf2c-0000-4f13-b654-146b8de04660
Walshe, N. D. A.
be7f840e-ec19-4a8b-b271-032dfa834dab

Black, G. P., Coles, S. J., Hizi, A., Howard-Jones, A. G., Hursthouse, M. B., McGown, A. T., Loya, S., Moore, C. G., Murphy, P. J., Smith, N. K. and Walshe, N. D. A. (2001) Synthesis and biological activity of analogues of ptilomycalin A. Tetrahedron Letters, 42 (19), 3377-3381. (doi:10.1016/S0040-4039(01)00400-2).

Record type: Article

Abstract

Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.

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Published date: 7 May 2001

Identifiers

Local EPrints ID: 19412
URI: https://eprints.soton.ac.uk/id/eprint/19412
ISSN: 0040-4039
PURE UUID: 9114286d-21a2-4a83-8e95-a65a60d61ee0
ORCID for S. J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

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Date deposited: 14 Feb 2006
Last modified: 06 Jun 2018 12:54

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Contributors

Author: G. P. Black
Author: S. J. Coles ORCID iD
Author: A. Hizi
Author: A. G. Howard-Jones
Author: A. T. McGown
Author: S. Loya
Author: C. G. Moore
Author: P. J. Murphy
Author: N. K. Smith
Author: N. D. A. Walshe

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