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Viral zoonoses and food of animal origin: caliciviruses and human disease

Clarke, Ian N. and Lambden, Paul R. (1997) Viral zoonoses and food of animal origin: caliciviruses and human disease In, Kaaden, O-.R., Czerny, C.P. and Eichhorn, W. (eds.) Viral Zoonoses and Food of Animal Origin: A RE-Evaluation of Possible Hazards for Human Health. Berlin, DE, Springer Verlag pp. 141-152. (Archives of Virology. Supplement, 13).

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Caliciviruses are important veterinary and human pathogens. The viruses gain their name from characteristic cup-shaped structures seen on the virion surface by negative stain electron microscopy. In humans caliciviruses are a major cause of diarrhoeal disease. There are two fundamentally different genome structures amongst human caliciviruses. The Norwalk-like or small round structured viruses (SRSVs) are viruses that have an amorphous structure when viewed by EM, they have a genome composed of 3 major open reading frames (ORFs). These viruses cause epidemic gastroenteritis amongst all age groups. In contrast, the 'classic' human caliciviruses (HuCVs) display the typical calicivirus surface structure and have their capsid ORF fused to and contiguous with the non structural proteins forming one giant polyprotein. HuCVs are predominantly associated with paediatric infections and are only a minor cause of disease in humans. Spread of disease for both SRSVs and HuCVs is usually by faecal oral transmission. SRSVs are a major cause of foodborne gastroenteritis especially linked to the consumption of sewage-contaminated shellfish. However, there is no evidence that these viruses replicate in shellfish or that they originate from an animal source.

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Published date: 1997


Local EPrints ID: 194269
ISBN: 3211830146
ISSN: 0939-1983
PURE UUID: 87253995-dc9a-4624-89ee-be358775bc48
ORCID for Ian N. Clarke: ORCID iD

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Date deposited: 26 Jul 2011 13:42
Last modified: 18 Jul 2017 11:27

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Author: Ian N. Clarke ORCID iD
Author: Paul R. Lambden
Editor: O-.R. Kaaden
Editor: C.P. Czerny
Editor: W. Eichhorn

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