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Identification of sequence selective receptors for peptides with a carboxylic acid terminus

Identification of sequence selective receptors for peptides with a carboxylic acid terminus
Identification of sequence selective receptors for peptides with a carboxylic acid terminus
Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.
combinatorial chemistry, peptides, receptors, tweezers, nonmacrocyclic 2-armed receptors, solid-phase synthesis, binding-properties, combinatorial library, artificial receptors, molecular tweezers, water, recognition, amides, complexation
0947-6539
1889-1898
Braxmeier, Tobias
94aa1f89-c4b9-4605-9a61-19204028b12b
Demarcus, Mariangela
e2840343-34b4-4446-89ef-0dac6a1cfb7d
Fessmann, Thilo
7e2f0f72-5e1e-475f-99f2-01cd1f38d341
McAteer, Stephen
01407229-8400-4469-ac4c-31cda590b021
Kilburn, Jeremy D.
e64ded70-825a-40ec-816b-c4605e007e7a
Braxmeier, Tobias
94aa1f89-c4b9-4605-9a61-19204028b12b
Demarcus, Mariangela
e2840343-34b4-4446-89ef-0dac6a1cfb7d
Fessmann, Thilo
7e2f0f72-5e1e-475f-99f2-01cd1f38d341
McAteer, Stephen
01407229-8400-4469-ac4c-31cda590b021
Kilburn, Jeremy D.
e64ded70-825a-40ec-816b-c4605e007e7a

Braxmeier, Tobias, Demarcus, Mariangela, Fessmann, Thilo, McAteer, Stephen and Kilburn, Jeremy D. (2001) Identification of sequence selective receptors for peptides with a carboxylic acid terminus. Chemistry - A European Journal, 7 (9), 1889-1898. (doi:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7).

Record type: Article

Abstract

Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.

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More information

Published date: 2001
Keywords: combinatorial chemistry, peptides, receptors, tweezers, nonmacrocyclic 2-armed receptors, solid-phase synthesis, binding-properties, combinatorial library, artificial receptors, molecular tweezers, water, recognition, amides, complexation

Identifiers

Local EPrints ID: 19427
URI: http://eprints.soton.ac.uk/id/eprint/19427
ISSN: 0947-6539
PURE UUID: a38c3b56-16f4-46d6-8f38-d18b7f40339a

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Date deposited: 14 Feb 2006
Last modified: 15 Jul 2019 19:27

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