Relationship of vitamin D status to adult lung function and COPD
Relationship of vitamin D status to adult lung function and COPD
Background: There is considerable interest in the possible role of vitamin D in respiratory disease, but only one population-based study has reported associations with lung function.
Methods: The cross-sectional relationships of total dietary vitamin D intake, serum 25 hydroxy vitamin D (25(OH)D) concentrations and three vitamin D receptor (VDR) polymorphisms (Apa1, Fok1 and Cdx2) with lung function and spirometrically-defined chronic obstructive pulmonary disease (COPD) were investigated in men and women aged 59–73 years in the Hertfordshire Cohort Study, UK.
Results: After controlling for confounders, total vitamin D intake was positively associated with forced expiratory volume in 1 s (FEV1; difference in FEV1 between top and bottom quintiles of intake 0.079 l (95% CI 0.02 to 0.14), p trend=0.007, n=2942), ratio of FEV1 to forced vital capacity (FEV1/FVC; p trend=0.008) and negatively associated with COPD (OR comparing top and bottom quintiles 0.57 (95% CI 0.38 to 0.87), p trend=0.02). In contrast, serum 25(OH)D concentrations were not related to FEV1 (p trend=0.89, n=1197) but were positively associated with COPD (p trend=0.046). VDR genotypes were unrelated to lung function and did not modify the effects of dietary intake or 25(OH)D concentrations on lung function.
Conclusions: The results of this study did not confirm a positive association between blood 25(OH)D concentrations and adult lung function. The apparent relationships with dietary vitamin D are likely to be explained by other highly correlated nutrients in the diet.
692-698
Shaheen, Seif O.
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Jameson, Karen A.
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Robinson, Sian M.
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Boucher, Barbara J.
de5e1d47-d10f-4c10-be36-8bb5f54361ff
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
8 June 2011
Shaheen, Seif O.
42e3b3fc-c70c-49e7-8c88-64f2606129ec
Jameson, Karen A.
d5fb142d-06af-456e-9016-17497f94e9f2
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Boucher, Barbara J.
de5e1d47-d10f-4c10-be36-8bb5f54361ff
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Shaheen, Seif O., Jameson, Karen A., Robinson, Sian M., Boucher, Barbara J., Syddall, Holly E., Aihie Sayer, Avan, Cooper, Cyrus, Holloway, John W. and Dennison, Elaine M.
(2011)
Relationship of vitamin D status to adult lung function and COPD.
Thorax, 66 (8), .
(doi:10.1136/thx.2010.155234).
(PMID:21653927)
Abstract
Background: There is considerable interest in the possible role of vitamin D in respiratory disease, but only one population-based study has reported associations with lung function.
Methods: The cross-sectional relationships of total dietary vitamin D intake, serum 25 hydroxy vitamin D (25(OH)D) concentrations and three vitamin D receptor (VDR) polymorphisms (Apa1, Fok1 and Cdx2) with lung function and spirometrically-defined chronic obstructive pulmonary disease (COPD) were investigated in men and women aged 59–73 years in the Hertfordshire Cohort Study, UK.
Results: After controlling for confounders, total vitamin D intake was positively associated with forced expiratory volume in 1 s (FEV1; difference in FEV1 between top and bottom quintiles of intake 0.079 l (95% CI 0.02 to 0.14), p trend=0.007, n=2942), ratio of FEV1 to forced vital capacity (FEV1/FVC; p trend=0.008) and negatively associated with COPD (OR comparing top and bottom quintiles 0.57 (95% CI 0.38 to 0.87), p trend=0.02). In contrast, serum 25(OH)D concentrations were not related to FEV1 (p trend=0.89, n=1197) but were positively associated with COPD (p trend=0.046). VDR genotypes were unrelated to lung function and did not modify the effects of dietary intake or 25(OH)D concentrations on lung function.
Conclusions: The results of this study did not confirm a positive association between blood 25(OH)D concentrations and adult lung function. The apparent relationships with dietary vitamin D are likely to be explained by other highly correlated nutrients in the diet.
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Published date: 8 June 2011
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Local EPrints ID: 194299
URI: http://eprints.soton.ac.uk/id/eprint/194299
ISSN: 0040-6376
PURE UUID: c7439bf2-aae3-4660-a3f0-6bc90c1811aa
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Date deposited: 26 Jul 2011 14:39
Last modified: 18 Mar 2024 02:48
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Author:
Seif O. Shaheen
Author:
Sian M. Robinson
Author:
Barbara J. Boucher
Author:
Avan Aihie Sayer
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