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The VP3 gene of human group C rotavirus

Samarbaf-Zadeh, Ali Reza, Lambden, Paul R., Green, Steve, Deng, Yu, Caul, E. Owen and Clarke, Ian N. (1996) The VP3 gene of human group C rotavirus Virus Genes, 13, (2), pp. 169-173. (doi:10.1007/BF00568909). (PMID:8972570).

Record type: Article

Abstract

The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence motifs. Human group C rotavirus genome segment 4 is 2,166bp long and encodes a single open reading frame of 2,082 nucleotides (693 amino acids) starting at nucleotide 55 and terminating at nucleotide 2,136 giving a 3' untranslated region of 30 nucleotides. Alignment with the porcine group C VP3 equivalent gene showed the human gene is one amino acid longer, and that the proteins have 84.1% amino acid sequence identity. A conserved potential nucleotide binding motif shared with the porcine VP3 sequence was identified. Analogy with the group A rotaviruses suggested that the genome segment 4 encodes the group C rotavirus guanylyltransferase.

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More information

Published date: January 1996
Keywords: rotavirus, dsrna, vp3 gene

Identifiers

Local EPrints ID: 194303
URI: http://eprints.soton.ac.uk/id/eprint/194303
ISSN: 0920-8569
PURE UUID: fba187df-7292-4ab5-bf78-be54656e006a
ORCID for Ian N. Clarke: ORCID iD orcid.org/0000-0002-4938-1620

Catalogue record

Date deposited: 27 Jul 2011 08:52
Last modified: 18 Jul 2017 11:27

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Contributors

Author: Ali Reza Samarbaf-Zadeh
Author: Paul R. Lambden
Author: Steve Green
Author: Yu Deng
Author: E. Owen Caul
Author: Ian N. Clarke ORCID iD

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