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Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization

Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization
Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization
A series of norbornene derivatives containing nucleic-acid bases (thymine, adenine, cytosine, guanine, or uracil) have been prepared as monomers for ring-opening-metathesis-polymerization (ROMP). Many of the initially prepared monomers had poor solubility but this could be overcome by appropriate choice of a linker between the norbornene and base units. Some of the monomers were successfully polymerised to give homopolymers derived from nucleic-acid bases.
c-13 magnetic-resonance, solid-phase synthesis, amino-acids, functionalized norbornenes, bearing nucleobases, strand displacement, building-blocks, pna monomers, analogs, dna
0300-922X
3365-3381
Davies, R. Gareth
d5dfe942-fe1f-4c20-92bb-1650cd703b34
Gibson, Vernon C.
e1623bb9-29c4-490f-9b26-a5e3771ba05f
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Marshall, Edward L.
1aa28715-4505-4522-baf7-613aa1d37933
North, Michael
7594caff-a25b-4981-adb8-56dcaa145ac7
Robson, David A.
14d63cb8-0d2f-42d3-a220-0dc0d28cccc9
Thompson, Ian
b6921c31-3afa-46bd-8991-ab55f9469027
White, Andrew J.P.
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Williams, David J.
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Williams, Paul J.
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Davies, R. Gareth
d5dfe942-fe1f-4c20-92bb-1650cd703b34
Gibson, Vernon C.
e1623bb9-29c4-490f-9b26-a5e3771ba05f
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Marshall, Edward L.
1aa28715-4505-4522-baf7-613aa1d37933
North, Michael
7594caff-a25b-4981-adb8-56dcaa145ac7
Robson, David A.
14d63cb8-0d2f-42d3-a220-0dc0d28cccc9
Thompson, Ian
b6921c31-3afa-46bd-8991-ab55f9469027
White, Andrew J.P.
09c64321-ac83-40be-a22c-3d62e4b19a7e
Williams, David J.
b6a3f659-e550-4783-bd23-3c6c30fd46db
Williams, Paul J.
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Davies, R. Gareth, Gibson, Vernon C., Hursthouse, Michael B., Light, Mark E., Marshall, Edward L., North, Michael, Robson, David A., Thompson, Ian, White, Andrew J.P., Williams, David J. and Williams, Paul J. (2001) Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization. Journal of the Chemical Society, Perkin Transactions 1, (24), 3365-3381. (doi:10.1039/b107139d).

Record type: Article

Abstract

A series of norbornene derivatives containing nucleic-acid bases (thymine, adenine, cytosine, guanine, or uracil) have been prepared as monomers for ring-opening-metathesis-polymerization (ROMP). Many of the initially prepared monomers had poor solubility but this could be overcome by appropriate choice of a linker between the norbornene and base units. Some of the monomers were successfully polymerised to give homopolymers derived from nucleic-acid bases.

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More information

Published date: 2001
Keywords: c-13 magnetic-resonance, solid-phase synthesis, amino-acids, functionalized norbornenes, bearing nucleobases, strand displacement, building-blocks, pna monomers, analogs, dna

Identifiers

Local EPrints ID: 19465
URI: http://eprints.soton.ac.uk/id/eprint/19465
ISSN: 0300-922X
PURE UUID: d11fa86f-153c-44dc-b676-897a059f4945
ORCID for Mark E. Light: ORCID iD orcid.org/0000-0002-0585-0843

Catalogue record

Date deposited: 15 Feb 2006
Last modified: 03 Dec 2019 01:55

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Contributors

Author: R. Gareth Davies
Author: Vernon C. Gibson
Author: Mark E. Light ORCID iD
Author: Edward L. Marshall
Author: Michael North
Author: David A. Robson
Author: Ian Thompson
Author: Andrew J.P. White
Author: David J. Williams
Author: Paul J. Williams

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