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Animal models of asthma: value, limitations and opportunities for alternative approaches

Holmes, Anthony M, Solari, Roberto and Holgate, Stephen T. (2011) Animal models of asthma: value, limitations and opportunities for alternative approaches Drug Discovery Today, 16, (15-16), pp. 659-670. (doi:10.1016/j.drudis.2011.05.014). (PMID:21723955).

Record type: Article

Abstract

Asthma remains an area of considerable unmet medical need. Few new drugs have made it to the clinic during the past 50 years, with many that perform well in preclinical animal models of asthma, failing in humans owing to lack of safety and efficacy. The failure to translate promising drug candidates from animal models to humans has led to questions about the utility of in vivo studies and to demand for more predictive models and tools based on the latest technologies. Following a workshop with experts from academia and the pharmaceutical industry, we suggest here a disease modelling framework designed to better understand human asthma, and accelerate the development of safe and efficacious new asthma drugs that go beyond symptomatic relief.

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Published date: 23 June 2011
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 194685
URI: http://eprints.soton.ac.uk/id/eprint/194685
ISSN: 1359-6446
PURE UUID: dada40d7-28ee-4e93-a496-6246d180d31d

Catalogue record

Date deposited: 09 Aug 2011 14:27
Last modified: 18 Jul 2017 11:26

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Contributors

Author: Anthony M Holmes
Author: Roberto Solari

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