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Interpretation and use of FRAX in clinical practice.

Interpretation and use of FRAX in clinical practice.
Interpretation and use of FRAX in clinical practice.
Summary: the introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review

Introduction: the International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review.

Methods: this study reviews the resource documents and joint position statements of ISCD and IOF.

Results: details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available.

Conclusions: the wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice
0937-941X
2395-2411
Kanis, J.A.
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Hans, D.
1986bda6-590a-40af-8f44-825462b7305e
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Baim, S.
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Bilezikian, J.P.
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Binkley, N.
db1bbdc5-b719-4bbd-b0e3-a0bf2a804319
Cauley, J.A.
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Compston, J.E.
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Dawson-Hughes, B.
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El-Hajj Fuleihan, G.
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Johansson, H.
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Leslie, W.D.
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Lewiecki, E.M.
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Luckey, M.
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Oden, A.
c018cdda-62cd-44a0-be3a-227484a568bb
Papapoulos, S.E.
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Poiana, C.
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Rizzoli, R.
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Wahl, D.
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McCloskey, E.V.
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Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Hans, D.
1986bda6-590a-40af-8f44-825462b7305e
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Baim, S.
0441bf80-a0ff-4061-b2f2-43b628b4e844
Bilezikian, J.P.
956b4a04-b893-43ef-b8b9-8637c51c1bcf
Binkley, N.
db1bbdc5-b719-4bbd-b0e3-a0bf2a804319
Cauley, J.A.
e34f09a1-b1ed-4c27-af06-380db358aa3c
Compston, J.E.
9ca6284a-7cfc-4674-bd0a-7ff4b323a910
Dawson-Hughes, B.
126652ed-871a-4982-be68-0b4db9254ec7
El-Hajj Fuleihan, G.
cd028094-ecf1-4f74-b076-1c82abb62028
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Leslie, W.D.
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Lewiecki, E.M.
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Luckey, M.
4e294e95-dadd-40c1-a291-2a35494d3246
Oden, A.
c018cdda-62cd-44a0-be3a-227484a568bb
Papapoulos, S.E.
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Poiana, C.
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Rizzoli, R.
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Wahl, D.
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McCloskey, E.V.
38518227-db8f-4a53-88a6-462f469151de

Kanis, J.A., Hans, D., Cooper, C., Baim, S., Bilezikian, J.P., Binkley, N., Cauley, J.A., Compston, J.E., Dawson-Hughes, B., El-Hajj Fuleihan, G., Johansson, H., Leslie, W.D., Lewiecki, E.M., Luckey, M., Oden, A., Papapoulos, S.E., Poiana, C., Rizzoli, R., Wahl, D. and McCloskey, E.V. (2011) Interpretation and use of FRAX in clinical practice. Osteoporosis International, 22 (9), 2395-2411. (doi:10.1007/s00198-011-1713-z). (PMID:21779818)

Record type: Article

Abstract

Summary: the introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review

Introduction: the International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review.

Methods: this study reviews the resource documents and joint position statements of ISCD and IOF.

Results: details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available.

Conclusions: the wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice

Full text not available from this repository.

More information

Published date: September 2011
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 194755
URI: http://eprints.soton.ac.uk/id/eprint/194755
ISSN: 0937-941X
PURE UUID: c72cbe5b-f462-48c9-9fe6-0afca357108e
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 10 Aug 2011 10:41
Last modified: 17 Dec 2019 01:56

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Contributors

Author: J.A. Kanis
Author: D. Hans
Author: C. Cooper ORCID iD
Author: S. Baim
Author: J.P. Bilezikian
Author: N. Binkley
Author: J.A. Cauley
Author: J.E. Compston
Author: B. Dawson-Hughes
Author: G. El-Hajj Fuleihan
Author: H. Johansson
Author: W.D. Leslie
Author: E.M. Lewiecki
Author: M. Luckey
Author: A. Oden
Author: S.E. Papapoulos
Author: C. Poiana
Author: R. Rizzoli
Author: D. Wahl
Author: E.V. McCloskey

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