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Cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review

Bryant, J., Picot, J., Levitt, G., Sullivan, I., Baxter, L. and Clegg, A. (2007) Cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review Health Technology Assessment, 11, (27), pp. 1-84. (doi:10.3310/hta11270). (PMID:17610809).

Record type: Article


It is difficult to draw conclusions about the effectiveness of technologies for reducing or preventing cardiotoxicity and about the use of cardiac markers in children as the evidence is limited in quantity and quality. The lack of standardisation for monitoring and reporting cardiac performance is problematic. Not all studies report effectiveness in terms of cardiac outcomes and event-free survival with supporting statistical analyses. Studies are mostly small and of short duration, making generalisation difficult. Increasing numbers of survivors of childhood cancer treated with anthracyclines will experience cardiac damage and require long-term surveillance and management. This will have an impact on cardiac services and costs. Diverse medical problems and other late sequelae that affect cardiac outcome will have an impact on other specialist services. Mechanisms to reduce or prevent cardiotoxicity from anthracycline therapy and cardiac markers to improve monitoring could alter the extent of this impact on service provision. RCTs of the different methods for reducing or preventing cardiotoxicity in children treated with anthracyclines for cancer with long-term follow-up are needed to determine whether the technologies influence the development of cardiac damage. Cost-effectiveness research is also required

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Published date: July 2007
Organisations: Faculty of Medicine


Local EPrints ID: 194783
ISSN: 1366-5278
PURE UUID: ef2373a4-0174-43f9-9c19-3c887b83baea
ORCID for J. Picot: ORCID iD

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Date deposited: 11 Aug 2011 11:31
Last modified: 18 Jul 2017 11:26

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Author: J. Bryant
Author: J. Picot ORCID iD
Author: G. Levitt
Author: I. Sullivan
Author: L. Baxter
Author: A. Clegg

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