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The clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrotic syndrome: a systematic review

The clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrotic syndrome: a systematic review
The clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrotic syndrome: a systematic review
The clinical effectiveness literature on treatments for idiopathic SRNS in children is very limited. The available evidence suggests a beneficial effect of ciclosporin on remission rates and of cyclophosphamide on time to remission; however, the strength of the conclusions drawn is limited by the poor quality of the included studies. The other treatments included in this review were each evaluated by only one study, and none found a statistically significant effect. There is insufficient evidence to determine whether or not there is a clinically significant difference. The available data on costs and outcomes are sparse and do not permit the reliable modelling of the cost-effectiveness of treatments for SRNS at present. A modelling framework is suggested, should more relevant data become available. A well-designed adequately powered randomised controlled trial comparing ciclosporin with other treatments in children with SRNS without genetic mutation is required
1366-5278
1-114
Colquitt, J.L.
741c69a3-d9e0-4f10-b457-e496541e7915
Kirby, J.
5cb348b3-e7cd-44f9-8382-7fa3b93a8580
Green, C.J.
d14dc500-f63a-4727-bd82-630f14a0ee50
Cooper, K.
ea064f58-d71d-404a-bcf3-49d243b8825b
Trompeter, R.S.
8098f0db-ff19-4e81-a496-a96088331e86
Colquitt, J.L.
741c69a3-d9e0-4f10-b457-e496541e7915
Kirby, J.
5cb348b3-e7cd-44f9-8382-7fa3b93a8580
Green, C.J.
d14dc500-f63a-4727-bd82-630f14a0ee50
Cooper, K.
ea064f58-d71d-404a-bcf3-49d243b8825b
Trompeter, R.S.
8098f0db-ff19-4e81-a496-a96088331e86

Colquitt, J.L., Kirby, J., Green, C.J., Cooper, K. and Trompeter, R.S. (2007) The clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrotic syndrome: a systematic review. Health Technology Assessment, 11 (21), 1-114. (doi:10.3310/hta11210). (PMID:17537341)

Record type: Article

Abstract

The clinical effectiveness literature on treatments for idiopathic SRNS in children is very limited. The available evidence suggests a beneficial effect of ciclosporin on remission rates and of cyclophosphamide on time to remission; however, the strength of the conclusions drawn is limited by the poor quality of the included studies. The other treatments included in this review were each evaluated by only one study, and none found a statistically significant effect. There is insufficient evidence to determine whether or not there is a clinically significant difference. The available data on costs and outcomes are sparse and do not permit the reliable modelling of the cost-effectiveness of treatments for SRNS at present. A modelling framework is suggested, should more relevant data become available. A well-designed adequately powered randomised controlled trial comparing ciclosporin with other treatments in children with SRNS without genetic mutation is required

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Published date: 2007
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 194785
URI: https://eprints.soton.ac.uk/id/eprint/194785
ISSN: 1366-5278
PURE UUID: 5622fcbb-fe58-44ef-9954-da2457a4c12f

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Date deposited: 11 Aug 2011 10:16
Last modified: 18 Jul 2017 11:26

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Contributors

Author: J.L. Colquitt
Author: J. Kirby
Author: C.J. Green
Author: K. Cooper
Author: R.S. Trompeter

University divisions

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